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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enhancing mammalian glycoprotein production in the baculovirus expression vector

    SBC: PARATECHS CORP.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitude of research projects. Like all expression systems, however, BEVS has its disadvantages. One is the fact that expression is short-lived due to vi ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Development of a Personalized Medicine Interface for the Safe and Effective Treat

    SBC: PHARMACOGENETICS DIAGNOSTIC LABORATORIES            Topic: NHLBI

    DESCRIPTION (provided by applicant): Improvements in the safety and efficacy of warfarin therapy will result from intelligent application of knowledge derived from inherited characteristics (CYP2C9 and VKORC1) of individual patients, only when this knowledge is applied through a standardized interventional approach. The fundamental pharmacologic influences of CYP2C9 and VKORC1 have been unequi ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Counterpulsation Device with Integrated ECG Sensing

    SBC: SCR, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Counterpulsation with an intra-aortic balloon pump has been widely and successfully used as a short term treatment for both acute and chronic cardiac dysfunction. SCR (Louisville, KY) is developing a novel chronic, implantable counterpulsation device (CPD) to treat late stage HF patients. The CPD is a 32-ml stroke volume polyurethane-lined blood chamber design ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE

    SBC: SILOAM BIOSCIENCES            Topic: NIDA

    The goal of this fast-track SBIR project is to develop the first ever, point-if-care test (POCT) to determine the ratio of nicotine metabolites

    SBIR Phase I 2010 Department of Health and Human Services
  5. Schweinfurthins: novel treatment for breast cancer

    SBC: TERPENOID THERAPEUTICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): According to the American Cancer Society an estimated 182,000 cases of invasive breast cancer occurred in the US in 2008, with 40,000 deaths due to breast cancer. Among women with metastatic breast cancer, the 5-year survival rate is 27%. The studies proposed in this SBIR phase I application are designed to assess the feasibility of developing synthetic schwein ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Generation of Site-Specific Recombinase-Expressing Transgenic Rats using an Enhan

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): The goal is to create site-specific recombinase (SSR)-expressing transgenic rats in an efficient and unbiased manner through a transposon-mediated in vivo gene trap. Rats are very relevant for modeling human biology and disease because rats, unlike mice, possess key biological similarities to humans. While in vitro gene trap mutagenesis is useful for gene d ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Creation of hyperactive transposons for mutagenesis in rodents

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The rat is a favored model for many types of human disease for which mice are not suitable. As opposed to the mouse, rats and humans also share more similarity in their cytochrome P450 genes, making the rat a more useful model for toxicology and pharmacology studies. The rat is also a favored model for diabetes, arthritis, behavioral disorders (including drug a ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Tissue and Airway Analysis for Emphysema Interventions

    SBC: VIDA DIAGNOSTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): With the considerable success of our phase 2 SBIR, we have achieved the completion of lung image analysis software that segments and thoroughly measures the lungs and their five lobes along with the airway tree. We have recently just achieved 510(k) FDA clearance for Pulmonary Workstation (PW 2.0) which now opens the door to the use of the Phase 2 software in t ...

    SBIR Phase II 2010 Department of Health and Human Services
  9. PURIFICATION, REFORMULATION AND PHARMACOKINETICS OF NITROSYLCO

    SBC: BNOAT ONCOLOGY, INC.            Topic: NCI

    Oncology remains a major market of unmet need. BNOAT Oncology¿s long-term objective is New Drug Approval of its lead candidate nitrosylcobalamin, a tumor-specific, apoptosis-inducing, anti-cancer drug. Research Design and Methods: Nitrosylcobalamin purification will include crystallizations, various chromatographic techniques including basic ion-exchange resins, neutral ion exchange, gel filtrati ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. High-fidelity clinical movement analysis with body mounted sensors

    SBC: ORCHARD KINETICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): High-fidelity clinical movement analysis with body mounted sensors Summary Clinical movement analysis is an important tool for management of orthopedic and neurological movement disorders. Despite scientific and clinical successes, this tool has not found widespread use in clinical practice outside of major research centers. One reason for this is the high cos ...

    SBIR Phase I 2010 Department of Health and Human Services

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