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SBC: Minnetronix Medical, Inc. Topic: 102
DESCRIPTION provided by applicant Directed Chemotherapy Delivery for Leptomeningeal Metastases PI Lad Shivanand and McCabe Aaron Project Summary Leptomeningeal Metastases LM is a condition in which cells from a primary solid or hematological tumor metastasize invade the subarachnoid space and spread throughout the cerebrospinal fluid CSF resulting in seeding of the leptomeninges along ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Nitinetics LLC Topic: NIDCD
DESCRIPTION provided by applicant Of all the hundreds of types of synthetic middle ear implants that are used in surgery approximately of these are rejected by the body These include total ossicular replacement prostheses TORPs and partial ossicular replacement prostheses PORPs TORPs are used in general when during surgery it is noted that the malleus incus and stapes are all absen ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Epigenetix Inc Topic: R41
PROJECT SUMMARY This proposal aims to develop a new small molecule drug to be advanced into human clinical trials for the treatment of cocaine addiction According to the National Institute on Drug Abuse illicit drug use cost the United States more than $ billion annually in expenses related to crime lost work productivity and health care Approximately million Americans aged or older ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: H-CUBED Topic: NHLBI
DESCRIPTION provided by applicant Congenital diaphragmatic hernia CDH affects in newborns CDH is a disorder in which part of the diaphragm fails to form allowing abdominal organs to migrate into the chest resulting in lung hypoplasia underdevelopment in affected infants Although great strides have been made in the management of this disease significant morbidity and mortality p ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
"Speed Bumps": A non-invasive quantitative test for early detection of neuropathy in the feetSBC: Neuro Devices, Inc. Topic: 101
ABSTRACT This STTR Phase I resubmission describes a small deceptively simple portable device called Speed Bumps that rapidly quantifies the sensation of flutter on the feet toes or fingers in micrometer m units Flutter frequency is to Hz which is below the approximate lower vibration range of to Hz This high sensitivity device is designed to differentiate the small variati ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: LIFE SERVICES L.L.C. Topic: 101
DESCRIPTION provided by applicant For this Phase I STTR proposal the investigators plan to develop the radiofrequency RF coil technology required for high resolution fMRI at T In the absence of a body transmit coil all T head coils must also incorporate a transmitter in addition to the receiver Here we propose a transmit array with up to individual channels combined with a receive a ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: ZANSORS LLC Topic: NICHD
DESCRIPTION provided by applicant This STTR grant is aimed to reduce pain from repeated needle pricks by improving the monitoring of glucose homeostasis GH in neonates by developing a real time glucose monitoring device The innovation utilizes a micro needle based lab on a patch platform invented by STTR partner George Washington University GWU GH is usually monitored by blood test via a ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: O2 RegenTech LLC Topic: 200
DESCRIPTION provided by applicant Oxygen plays a significant role in wound healing and maintaining elevated tissue oxygenation levels are an important factor in the dermal healing response Specifically non healing diabetic chronic wounds defined as lasting andgt weeks often show devastatingly low oxygen concentrations as low as mmHg oxygen partial pressure In the USA there are more ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Development of a novel platform to enhance intracellular bioavailability of antisense morpholino oligomersSBC: NAJIT TECHNOLOGIES INC Topic: NIAID
DESCRIPTION provided by applicant Peptide conjugated phosphorodiamidate morpholino oligomers PPMO are single stranded nucleic acid analogs able to modulate gene expression through steric blocking of complementary RNA PPMO are composed of two components an antisense morpholino oligomer cargo covalently conjugated to a cell penetrating delivery peptide PPMO are completely nuclease resistant ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: ADVANCED MEDICAL ELECTRONICS CORP Topic: NIA
DESCRIPTION provided by applicant Insomnia of sufficient clinical severity to meet diagnostic criteria is present in approximately of older adults nearly million individuals n the US alone If left untreated it can lead to increased rates of depression cognitive impairment and cardiovascular disease Treatment relies on pharmacotherapy such as sedative hypnotic therapy which is ass ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health