Award Data

WHILE MEDICINE GENERALLY AND HEALTH CARE SPECIFICALLY HAVE BECOME INCREASINGLY DEPENDENT UPON COMPUTERS FOR DIAGNOSTICS, INFORMATION MANAGEMENT, AND EVEN NEW CAPABILITIES (E.G., CAT SCANNERS), ONE AREA THAT HAS NOT DERIVED THE FULL BENEFIT OF MODERN COMPUTING IS QUALITY ASSURANCE. THE RAPIDLY FALLING PRICE OF COMPUTERS, THE EXPONENTIAL INCREASE IN THEIR CAPABILITIES, AND THE MATURINGOF THE COMPUTE ...

METRACO, INC. PROPOSES TO DEVELOP A PROTOTYPE EVOKED-POTENTIAL INSTRUMENT THAT WILL ALLOW AUTOMATED SCREENING FOR HEARING PROBLEMS IN THE NEWBORN INFANT. THE INSTRUMENT WILL PROVIDE NEW, UNIQUE FEATURES AND TECHNOLOGY UNAVAILABLE IN EXISTING INSTRUMENTS. THE MAJOR GOALS ARE: (1) TO IMPROVE THE EFFECTIVE SIGNAL-TO-NOISE RATIO AND ERROR REDUCTION ABILITY BY COMPUTATION OF THE MEDIAN RATHER THAN THE ...

THE REDUCTIVE CONVERSION OF RIBONUCLEOTIDES TO DEOXYRIBONUCLEOTIDES, CATALYZED BY RIBONUCLEOTIDE REDUCTASE,IS A CRUCIAL AND RATE-LIMITING REACTION IN THE DNA BIOSYNTHETIC PATHWAY. THIS REACTION, THEREFORE, REPRESENTS A LOGICAL TARGET FOR CANCER CHEMOTHERAPY. IN RESPONSE TO THE NEED FOR AN EFFECTIVE AGENT AT THIS SITE, A SERIES OF RIBONUCLEOTIDE REDUCTASE INHIBITORS, BASED ON A VICINAL POLYHYDROXYP ...

A NOVEL HORIZONTAL LIGHT PATHVISION ENHANCING SYSTEM (HLP-VES) CAPABLE OF 2X TO 6X MAGNIFICATION AND MOUNTED ACROSS THE FACIAL PLANE WILL BE STUDIED 1. SURVEY OF CURRENT USAGE OF TELESCOPIC VISION AIDS; 2. OPTIMIZATION OF OPTICAL DESIGN IN DESIRABLE MAGNIFICATION POWERS INCORPORATING THE HLP-VES PRINCIPLE; 3. PRELIMINARY DESIGNS OF OPTICAL CHASSIS AND MOUNTING; 4. IDENTIFICATION OF COMPONENT SOURC ...

THE LONG-TERM RESEARCH OBJECTIVE IS TO MAKE COMMERCIALLY AVAILABLE A MICROCOMPUTER-BASED SYSTEM TO FACILITATE PATIENT SELF-CONTROL OF INSULIN DEPENDENT DIABETES MELLITUS. THIS COMPREHENSIVE ""DIABETES IN SELF-CONTROL (DISC) SYSTEM'' IS COMPOSED OF: 1.AN INSTRUCTIONAL AND REINFORCEMENT COMPONENT FOR COMPUTER ASSISTED HOME BLOOD GLUCOSE MONITORING; 2.A COMPONENT WHICH PROVIDES COMPUTER ASSISTED INST ...

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THE GOAL OF THIS PROJECT IS TO IMPROVE THE EXISTING PURIFICATION PROCEDURE, DEVELOPED BY PIEDMONT RESEARCH COMPANY, FOR THE 250 KD MELANOMA TUMOR-ASSOCIATED ANTIGEN (TAA) TO ALLOW PRODUCTION OF ADEQUATE QUANTITIES OF PURIFIEDTAA FOR CLINICAL EVALUATION. PURIFIED TAA MAY PROVE AN EFFICIENT AGENT FOR IMMUNOTHERAPY AND FOR SPECIFIC IN VITRO ACTIVATION OF PATIENT T CELLS FOR SUBSEQUENT THERAPY. BOTH T ...

PROGESTERONE RECEPTOR IS ONE OF A GROUP OF STEROID HORMONE RECEPTORS THAT HAS BEEN SHOWN TO HAVE IMPORTANT REGULATORY EFFECTS IN MAMMARY AND OTHER TARGET TISSUES. THE QUALITATIVE AND QUANTITATIVE DETERMINATION OF PROGESTERONE RECEPTOR IS USEFUL IN THE THERAPEUTIC MANAGEMENT OF BREAST CANCER. CURRENTLY, AVAILABLE ASSAYS FOR PROGESTERONE RECEPTOR HAVE DRAWBACKS THAT MAKE THEM DIFFICULT TO USE IN MOS ...

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RAD-IMAGE CORPORATION PROPOSES TO DEVELOP A PORTABLE, MICROCOMPUTER-CONTROLLED SCANNING DIGITIZER AND AUXILIARY DEVICES TO MEASURE: (1) X-RAY TARGET INTENSITY DISTRIBUTIONSDIRECTLY; (2) LIGHT INTENSITY DISTRIBUTIONS FROM FLUORESCENTSCREENS, IMAGE INTENSIFIERS, AND BACKLIGHTED, DEVELOPED X-RAY FILMS; AND (3) KILOVOLTAGE, X-RAY EXPOSURE, HALF-VALUELAYERS, AND TIME OF EXPOSURE. IT IS ALSO PLANNED TO ...