Award Data

PROJECT SUMMARYArsenic in drinking water poses a serious health hazard to tens of millions of peopleespecially in parts of the world where the arsenic concentrations far exceed theppb guideline value set by the World Health OrganizationAccording to a recent studyapproximatelyM people in the conterminous U Suse water from domestic wellsmillion out of themillion peopleare predicted to be using wells ...

Summary Cell free DNAcfDNAin peripheral blood contain tumor derived DNA and are promising noninvasive biomarkers for cancer therapy selection and recurrence monitoringHoweverthe high cost of current commercial next generation sequencingNGSpanels for profiling cancer mutations in cfDNA prevents them from being routinely usedFurthermorethe high sequencing depth and reads required means that cfDNA pr ...

Abstract Lyme disease, caused by infection with the spirochete Borrelia burgdorferi or closely related species, is the most common vector-borne disease in the United States, accounting for over 300,000 infections per year according to public health estimates. It is also one of the few infectious diseases that requires a two-step laboratory testing protocol, comprising a screening assay, typically ...

Summary Rat research models are established to investigate a broad spectrum of human health issues significant to most NIH Institutes and are reported in andgt;1.5 million publications listed on NCBI PubMed Central. Direct germline editing products and services generated by this SBIR project will streamline production of the most sophisticated, genetically designed rat models used to study gene, c ...

Project Summary Abstract Currently available anti thymocyte globulinATGproducts are polyclonal animal antibodiesATGAMequine polyclonal ATGThymoglobulinrabbit polyclonal ATGand have found broad use as immune tolerizing agentsparticularly for induction therapy in a majority of tissue transplantsfor acute transplant rejectionand as treatment for graft vshost disease following bone marrow transplantsE ...

PROJECT SUMMARY/ABSTRACT Marijuana Breath Analyzer The overall goal of this program is a THC breath analyzer that will provide rapid, accurate, and non-invasive determination of recent marijuana use at point-of-collection testing (POCT). Authorities will obtain breath samples noninvasively as they currently do in alcohol testing and receive the results on the spot. This field device for enforcemen ...

The DRUIDApp to Test ImpairmentAbstract The objective of this Fast Track proposal is to demonstrate proof of concept and efficacy of a portable cognitive behavioral assessment toolthe DRUIDappthat measures impairment from cannabisalcohol or other sourcesThis device will be available for use by military to assess mission readiness and training limitsfor workplaces and transportation systems to asse ...

PROJECT SUMMARY Multiple SclerosisMSis the most common neurological disease of early adulthood and is mediated by autoimmune mechanisms that lead to demyelination and neuronal damage in the central nervous systemresulting in progressive neurological dysfunctionThere is no cure for the disease and current treatments focus on preventing future immunological attacksmainly by suppressing the immune sy ...

Project Summary/Abstract The United States is experiencing an opioid epidemic of unprecedented scope. More than 6 out of 10 drug overdoses are now opioid-related, resulting in ~90 deaths/day. The economic impact of the epidemic has been estimated to exceed $75B/year, primarily from health and social costs related to prescription opioid use [Pain Med. 2011; 12(4):657-67. 2013; 14(10):1534-47]. New ...

RESEARCH andampRELATEDUnitPROJECT SUMMARY ABSTRACT In response to PAthe aim of this Phase I STTR proposal is to optimize and develop peripherally actingcannabinoidreceptorCB Rneutral antagonists displaying favorable therapeutic profiles for treating diabetic nephropathyDNDN is a chronic diabetic kidney disease and affectstypeand typediabetic patientsIt is characterized by persistent albuminuria an ...