Award Data

Project Summary Triple negative breast cancerTNBCis a subtype of breast cancerthat occurs in aboutof diagnosed breast cancerswhich is more likely to affect younger peopleAfrican AmericansHispanicsand or those with BRCAgene mutationThe projected TNBC annually diagnosed cases in United States are estimated to be more thanbyDue to the lack of the identified receptors on tumor cell surfaceTNBC patient ...

Project Summary This Small Business Innovation Research Phaseproject will develop a novel magnetic cytometer to rapidly isolateidentify and sort single intact and viable cells from heterogeneous cell population for single cell analysisSingle cell analysis is the key to investigate fundamental biological principles behind cell heterogeneity and disease evolutionSorting of single cells from heteroge ...

Development and Evaluation of a polymer coated proprietary cream formulation ofresiniferatoxin nanoparticles for the Treatment of Pain Associated with DiabeticPeripheral Neuropathy Diabetes is a major problem in developed and developing countriesIt is estimated thatmillion adults will have diabetes globally by yearOne of the major complications of diabetes is diabetic peripheral neuropathyDPNresul ...

Approximatelyof the population has unruptured cerebral aneurysmsapproximatelymillion people in the USAboutrupture per yearwith devastating consequencesAboutof patients with ruptured aneurysms dieandofwho survive have significant disabilitiesCoil embolization therapy is associated with a high rate of recurrenceFlow diverters are increasingly being used to cover the neck of the aneurysm providing mo ...

PROJECT SUMMARY The for profit small business concernTricorder Array Technologies LLCwill developin partnership with the University of Alabama at BirminghamSIDECAReSensing and Integrating Data for Environmental Conditions in Animal ResearchThis device will automate collection of relevant data that will enhance consistency in animal models used to study human health treatment researchOur innovative ...

Project Summary Abstract Oral vaccines have the potential to make a revolutionary improvement in the quality of life in developing countriesSince these vaccines can be administered by community health workers who are not trained medical personnelthe number of people who can be immunized in a short period of time is drastically increased while the cost per patient is significantly loweredOral vacci ...

PROJECT SUMMARY DeNovX and its collaborators in the Myerson Group at MIT are developing innovative approaches to improve crystallization of active pharmaceutical ingredients (APIs) and proteins. The goal of this Phase II grant is to expand the use of continuous flow crystallization using enhanced nucleation surfaces to the manufacture of small molecule therapeutics to improve efficiencies, economi ...

Influenza A viruses belong to the Orthomyxoviridae family with a negative-sense, segmented RNA genome, which can cause seasonal or pandemic flu with high morbidity and significant mortality. Vaccination is the most prevalent prophylactic means for controlling influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Furthermore, vac ...

ABSTRACT Native top down mass spectrometrynTDMSis a multi tiered tandem mass spectrometry technique able to characterize proteoforms and intact protein complexes in their native state and represents a potentially revolutionary technology still in theearly adoptersstage of the technology life cycleBy utilizing gentle sample preparation and analysis methodsnTDMS can provide a direct measure of the e ...

Project Summary AbstractMetolazone is a quinazoline sulfonamide with potent thiazide like diuretic activity on the cortical diluting segmentas well as diuretic action on the proximal tubuleMetolazoneorallyis often employed in patients with severe congestive heart failureCHFas a supplement to a loop diureticas well as in patients with diuretic resistance to loop diureticsHowevermetolazone has not b ...