Award Data

N/A

THIS PROPOSAL WILL DETERMINE THE MERIT AND FEASIBILITY OF A RECOMMENDED METHODOLOGIES (WHICH BEST LINK THE ADA DEVELOPMENT ENVIRONMENT, WITH THE RAPID PROTOTYPING DEVELOPMENT PROCESS ASSOCIATED WITH AI APPLICATIONS THAT ARE WRITTEN IN EITHER LISP OR PROLOG LANGUAGE) BY MAPPING BETWEEN APSE AND ASE AND THE MAPPING OF THE SUPPORT ENVIRONMENT INTO THE ADA SUPPORT ENVIRONMENT. THE SECOND SUB-PROBLEM I ...

THE AIM OF THIS PROPOSAL IS TO INVESTIGATE AND DEVELOP LONG-TERM IONTOPHORETIC PROCEDURES FOR DELIVERY OF NARCOTIC AGENTS. IONTOPHORESIS HAS BEEN KNOWN FOR A LONG TIME, BUT ITS APPLICATION IS LIMITED TO SHORT-TERM PROCEDURES (15 TO 30 MINUTES). THE MAJOR IMPEDIMENT TO LONG-TERM USE IS THE FORMATION OF ELECTROLYTIC PRODUCTS AT THE ELECTRODE, LOWERING THE EFFICIENCY OF DRUG TRANSPORT AND CAUSING BUR ...

THE AIM OF THIS PROPOSAL IS TO INVESTIGATE THE TISSUE-GROWTHENHANCEMENT CAPABILITIES OF FIBROUS POLYMERIC SUBSTRATES PRODUCED BY A NOVEL TECHNIQUE. THIS TECHNIQUE IS CAPABLE OFPRODUCING GEOMETRICALLY DEFINED, NONWOVEN MATS COMPOSED OF 0.1 TO 1.0MU DIAMETER FIBRILS. UNLIKE CONVENTIONAL FIBRILLATION TECHNIQUES, THE PROPOSED TECHNIQUE CAN UTILIZE A LARGE VARIETY OF POLYMERIC SOLUTIONS AS THE FIBRILLA ...

THE DETECTION AND CHARACTERIZATION OF PESTICIDES, INDUSTRIAL SOLVENTS, AND THEIR METABOLITES IN BODY FLUIDS AND TISSUES ARE IMPORTANT FOR EVALUATING THE POTENTIAL LONG-TERM HEALTH EFFECTS OF THE EXPOSED POPULATION. UNFORTUNATELY, ANALYTICAL METHODS PRESENTLY AVAILABLE ARE GENERALLY TEDIOUS, TIME-CONSUMING, COMPLEX OR NONSPECIFIC AND LACK REQUIRED SENSITIVITY. THIS STUDY WILL EVALUATE CAPILLARY SUP ...

THE ANALYSIS OF CANNABINOIDS FOR RESEARCH OR SCREENING FOR CANNABIS ABUSE REQUIRES METHODS CAPABLE OF CHARACTERIZING AND QUANTIFYING METABOLITES OF THE CANNABINOIDS WHICH ARE GENERALLY POLAR OR THERMALLY UNSTABLE AND WHICH MUST BE SEPARATED FROM A COMPLEX BIOLOGICAL MATRIX. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS PROPOSED AS A METHOD WHICH IS CAPABLE OF PROVIDING HIGH-RESOLUTION SEPARATION OF ...

GAS AND LIQUID CHROMATOGRAPHS ARE THE MOST ROUTINELY USED INSTRUMENTS IN ANALYTICAL AND CLINICAL LABORATORIES FOR THE ANALYSIS OF ORGANIC COMPOUNDS. THE OBJECTIVE OF LEE SCIENTIFIC, INC. IS TO MANUFACTURE AN INSTRUMENT THAT USES SUPERCRITICAL FLUIDS INSTEAD OF GASES OR LIQUIDS AS MOBILE PHASES. THE ABILITY TO SIGNIFICANTLY AFFECT SOLUTE SOLUBILITY IN THE SUPERCRITICAL FLUID MOBILE PHASE BY CHANGES ...

THE AIM OF THIS PROJECT IS TO DEMONSTRATE AN IMMUNOMETRIC ASSAY FOR CANDIDA ANTIGEN (MANNAN) USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL. THIS WILL LEAD TO A TECHNIQUE FOR THE DETECTION OF FUNGAL ANTIGENS THAT REQUIRES HIGH SENSITIVITY, BY A METHOD THAT IS SIMPLER, SAFER, AND CHEAPERTHAN CONVENTIONAL METHODS. MONOCLONAL ANTIBODIES TO CANDIDA MANNAN WILL BE PURIFIED AND CHARACTERIZED FOR TH ...

THE AIM OF THIS PROJECT IS TO DEMONSTRATE THE FEASIBILITY OF AN IMMUNOASSAY FOR INSULIN, USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL. THIS WILL LEAD TO A TECHNIQUE FOR THE DETECTION OF POLYPEPTIDE HORMONES THAT IS FASTER AND MORE SENSITIVE, AND REMOVES THE NEED FOR (125)I-LABELED PEPTIDES OR ANTIBODIES. THE PROJECT WILL EXPLORE BOTH TRADITIONAL IMMUNOASSAYS IN WHICH THE INSULIN MOLECULE IS ...

N/A