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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SURFACE MODIFICATION OF BIOMATERIALS FOR THROMBOSIS PREVENTION

    SBC: SURMODICS, INC.            Topic: N/A

    ALL SYNTHETIC MATERIALS THAT CONTACT BLOOD EXPERIENCE PROBLEMS WITH BLOOD COMPATIBILITY. THE RAPID ADSORPTION OF PLASMA PROTEINS AND SUBSEQUENT ADHERENCE AND ACTIVATION OF PLATELETS LEADS TO THROMBUS FORMATION. WHEN PATIENTS ARE IMPLANTED WITH VASCULAR DEVICES OR UNDERGO HEMODIALYSIS PROCEDURES, MAINTENANCE LEVELS OF ANTICOAGULANTS MUST BE GIVEN TO PREVENT LIFE-THREATENING CLOT FORMATIONS. HOWEVER ...

    SBIR Phase II 1992 Department of Health and Human Services
  2. CYCLODEXTRINS FOR SLOW-RELEASE ANTIBIOTIC COATING

    SBC: SURMODICS, INC.            Topic: N/A

    POLYMER-BASED INPLANTABLE DEVICES, SUCH AS URINARY TRACT CATHETERS, INTRAOCULAR LENSES, VASCULAR GRAFTS, AND PACEMAKER LEADS COMPRISE 80% OF ALL NON-ORTHOPEDIC IMPLANTABLE DEVICES, AND THE NUMBER IS EXPECTED TO INCREASE IN THE FUTURE. UNFORTUNATELY, POLYMER SURFACES ARE INHERENTLY SUBJECT TO ALARMINGLY HIGH DEVICE-CENTERED INFECTION RATES. SINCE SYSTEMIC TREATMENT WITH CONVENTIONAL ANTIBIOTICS DOE ...

    SBIR Phase I 1992 Department of Health and Human Services
  3. SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES

    SBC: SURMODICS, INC.            Topic: N/A

    THE MOST COMMON PROBLEM WITH CURRENT BREAST PROSTHESES IS THE DEVELOPMENT OF A CONTRACTILE FIBROUS CAPSULE. CAPSULAR CONTRACTURE PRODUCES BREAST HARDINING, PAIN, AND DISTORTION OF THE BREAST SHAPE. THIS PHASE I PROJECT WILL COMBINE TWO TYPES OF PROSTHESIS SURFACE MODIFICATIONS TO REDUCE CAPSULE FORMATION AND CONTRACTURE. FIRST, THE PROSTHESIS TO BE USED WILL HAVE A TEXTURE (POROUS) SILICONE RUBBER ...

    SBIR Phase I 1992 Department of Health and Human Services
  4. PHOTOCHEMICAL MODIFICATION OF HYBRIDIZATION MEMBRANES

    SBC: SURMODICS, INC.            Topic: N/A

    THE NUMBER OF NUCLEIC ACIDS TO MEMBRANE FILTERS HAS PROVIDED A NUMBER OF APPLICATIONS FOR MOLECULAR HYBRIDIZATION INCLUDING THE ANALYSIS OF GENOME STRUCTURE AND FUNCTION AND DIAGNOSIS OF INFECTIOUS DISEASES AND GENETIC DISORDERS. THE SENSITIVITY AND REPRODUCIBILITY OF THE HYBRIDIZATION REACTION DEPEND ON THE PROPERTIES OF THE MEMBRANE USED. BSI HAS DEVELOPED A PROPRIETARY PHOTOIMMOBILIZATION TECHN ...

    SBIR Phase I 1992 Department of Health and Human Services
  5. Surface Modifying to Improve Urinary Catheter Function

    SBC: SURMODICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 1992 Department of Health and Human Services
  6. THE SOUND CANCELLATION STETHOSCOPE

    SBC: Biosonics            Topic: N/A

    THERE CURRENTLY EXISTS NO DEPENDABLE STETHOSCOPE FOR USE IN HIGH NOISE ENVIRONMENTS. ALL AVAILABLE MODELS SUFFER SOUND DEGRADATION AT ONE OR MORE POINTS WHEN USED IN THE PRESENCE OF HIGH AMBIENT NOISE. UNFORTUNATELY, PATIENTS IN SUCH ENVIRONMNETS ARE OFTEN CRITICALLY ILL, AND THE STETHPSCOPE REMAINS A KEY TOOL IN THER IMMEDIATE EVALUATION AND TREATMENT. ANY IMPROVEMENT IN THE PHYSICIAN'S ABILITY T ...

    SBIR Phase I 1992 Department of Health and Human Services
  7. A FAMILY-ORIENTED PLANNING SYSTEM FOR PRIMARY PREVENTION

    SBC: Brimson Laboratories            Topic: N/A

    N/A

    SBIR Phase I 1992 Department of Health and Human Services
  8. DELIVERY OF SOUND DEEPER INTO THE DYNAMIC HUMAN EAR

    SBC: Hearing Components, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1992 Department of Health and Human Services
  9. USING COMPUTER ANIMATION IN HEALTH EDUCATION VIDEOS

    SBC: Information Technology Design            Topic: N/A

    THIS PROJECT WILL DEVELOP AND EVALUATE HEALTH-PROMOTING INSTRUCTIONAL VIDEOS THAT USE ANIMATION COMBINED WITH LIVE VIDEO. DESKTOP VIDEO SOFTWARE WILL BE USED TO PRODUCE SAMPLE VIDEO LESSONS. USING AN EXPERIMENTAL DESIGN, THE COGNITIVE AND ATTITUDINAL IMPACT OF THESE LESSONS ON CHILDREN IN VARIOUS TREATMENT CONDITIONS WILL BE EVALUATED. BECAUSE OF ITS ABILITY TO GAIN AND HOLD THE ATTENTION OF CHILD ...

    SBIR Phase II 1992 Department of Health and Human Services
  10. ISOTHIOCYNATE CONJUGATES AS CANCER CHEMOPREVENTIVES

    SBC: LKT LABORATORIES, INC.            Topic: N/A

    THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP A SERIES OF WATER SOLUBLE CONJUGATES OS ISOTHIOCYANATES AS A NOVEL TYPE OF PRODRUG WITH SITE SPECIFICITY AND LESS TOXICITY AGAINST BLADDER AND COLON CANCER. THE APPROACH TO THE DESIGN OF PRODRUGS IS BASED ON THE OBSERVATION THAT WHEN ISOTHIOCYANATES WERE ADMINISTERED TO ANIMALS OR HUMANS, THEIR CORRESPONDING CONJUGATES APPEARED AS PRINCIPAL URINARY METAB ...

    SBIR Phase I 1992 Department of Health and Human Services

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