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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Bispecific Antibody Based Immunotherapy for Triple Negative Breast Cancer

    SBC: Dualogics LLC            Topic: 102

    Development of a Bispecific Antibody Based Immunotherapy for Triple Negative Breast Cancer SUMMARY ABSTRACT A promising and versatile approach to cancer treatment is the use of bispecific antibodies bsAb for immune cell redirection In the two clinically approved therapies that pioneered this strategy a bsAb drug acts as a molecular bridge between a T cell via CD binding and a tumor cell v ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Novel nanoparticle based enzyme replacement therapy for Hunter Syndrome

    SBC: NEURO10-9 PHARMA INC            Topic: 100

    ABSTRACT Significance With overall prevalence of live births lysosomal storage diseases LSD as a class are one of the most common childhood diseases LSD are caused by lysosomal dysfunction mainly due to lysosomal enzyme mutations and are usually fatal in the first two decades of life CNS pathology is present in of LSD however currently marketed enzyme replacement therapy ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Validation of a Performance Based Measure of Functioning in MCI and Early AD

    SBC: NEUROCOG TRIALS            Topic: NIA

    Project Summary Alzheimer s disease AD is expected to rise in prevalence from to million Americans by leading to of deaths among adults over This epidemic is projected to overwhelm healthcare and economic resources with costs reaching $ billion in the US in and $ trillion by There is no cure for AD and no new drugs have been successful in treating the advance ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical evaluation of the novel uni directional Pd CivaSheet for Lung Cancer

    SBC: CIVATECH ONCOLOGY, INC.            Topic: 102

    CivaTech Oncology s mission is to provide improved radiation therapy directly to localized tumors The Company has developed a novel polymer encapsulated membrane like radiation source that emits radiation on only one side of the device the CivaSheet This directional source is compatible with open and minimally invasive surgical techniques and has FDA clearance to be used as primary or combin ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Detecting breast cancer with a simple blood test using an accessible and low cost novel real time platform

    SBC: Inanovate, Inc.            Topic: 102

    Project Summary Although widespread screening by mammography has successfully cut mortality from breast cancer BCa the exquisite sensitivity of the technique results in a startling number of false positives Of approximately million women who receive a positive mammogram each year fewer than will be diagnosed with BCa Cumulatively the economic cost of follow up diagnostic ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Implantable iontophoresis chemotherapy delivery device for direct infusion of gemcitabine into pancreatic adenocarcinoma Device development and First in Human clinical trial

    SBC: Advanced Chemotherapy Technologies            Topic: 102

    PROJECT SUMMARY Advanced Chemotherapy Technologies ACT has developed a proprietary implantable iontophoretic device that facilitates the infusion of chemotherapy agents directly into a cancer tumor minimizing toxic exposure to the vascular system and other organs ACT is focusing specifically on treating pancreatic cancer with gemcitabine for this proposal Pancreatic cancer has a five year sur ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a first in class therapeutic for producing on demand voiding

    SBC: Dignify Therapeutics LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT Aging and diabetes as well as many neurological conditions such as multiple sclerosis Parkinsonandapos s disease spina bifida stroke and spinal cord injury SCI can result in loss of voluntary voiding of urine and require intermittent bladder catheterization for voiding Catheter use is associated with increased incidence of health problems predominately repeate ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. The Impact Integrated Data System for Quality and Outcomes Tracking of Prevention Programs

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    Abstract There has been substantial progress in developing evidence based prevention programs EBPPs for preventing risky behaviors and promoting positive mental health outcomes for youth Unfortunately EBPP adoption quality implementation long term sustainability and scalability in real world service settings continues to lag far behind jeopardizing the ability to achieve the intended broad ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    Abstract It is estimated that only about of young patients suffering from!activity limiting hip osteoarthritis OA choose to undergo traditional hip replacement surgery This low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased ef ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Microfluidic Biotool to Accurately Model Corrosive Chemical Exposures for Human

    SBC: SCIKON INNOVATION, INC.            Topic: NIEHS

    Project Summary There is a critical gap between the need to evaluate the effect of chemicals on human physiology and the availability of in vivo and in vitro testing systems that provide the necessary predictive data This need is especially pronounced for corrosive and caustic chemicals that are not compatible with current in vitro and in vivo testing systems For example the Toxic Substances Co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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