Award Data

Project Summary The elderly population is rapidly increasing worldwide and those over years old are expected to comprise of the total population by These demographic changes will focus healthcare needs on those conditions more prevalent in the elderly Chronic wounds such as venous leg ulcers pressure ulcers and diabetic ulcers are over represented in the elderly population and even ...

We propose to produce a simulation experience to ensure that clinical year medical students are prepared for have coping strategies to deal with and are more resilient to the stresses and challenges that await them as they transition to clinical practice and learning in a clinical environment The experience will guide institutional level change by anonymously communicating studentsandapos conc ...

PROJECT SUMMARY ABSTRACT Underactive bladder UAB is a condition wherein a bladder contraction of reduced strength and or duration results in prolonged bladder emptying and or a failure to achieve complete bladder emptying within a normal time span The overarching hypothesis of this application is that in the absence of physiologically induced bladder contractions pharmacologically induced co ...

PROJECT SUMMARY It is estimated thatof anti cancer small molecules and up toof late stage investigational compounds are poorly soluble in waterand such compounds are often associated with significant clinical problemssuch as inconsistent dosing and variable pharmacokineticsPKDasatinib is an orally bioavailable tyrosine kinase inhibitorTKIindicated for the treatment of chronic myelogenous leukemiaC ...

Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

SUMMARY ABSTRACT Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations Overexpression of hepcidin results in severe iron deficiency and anemia whereas hepcidin deficiency leads to iron overload Not surprisingly abnormalities in hepcidin production and circulating concentrations are highly correlated with various disease states such as renal disease cancer ...

Development of a Bispecific Antibody Based Immunotherapy for Triple Negative Breast Cancer SUMMARY ABSTRACT A promising and versatile approach to cancer treatment is the use of bispecific antibodies bsAb for immune cell redirection In the two clinically approved therapies that pioneered this strategy a bsAb drug acts as a molecular bridge between a T cell via CD binding and a tumor cell v ...

PROJECT ABSTRACT Diabetesa chronic disease associated with significant morbidity and mortalityis disproportionately represented in African AmericansDiabetes self management education and supportDSME Sis crucial to delaying or preventing disease progressionhoweverlack of access to proper healthcare due to financialculturalknowledgegeographicor physical barriers places this disadvantaged population ...

ABSTRACT Significance With overall prevalence of live births lysosomal storage diseases LSD as a class are one of the most common childhood diseases LSD are caused by lysosomal dysfunction mainly due to lysosomal enzyme mutations and are usually fatal in the first two decades of life CNS pathology is present in of LSD however currently marketed enzyme replacement therapy ...

PROJECT SUMMARY Underactive bladderUABis a clinically important problem in the elderlyUAB is characterized by weak bladder contractions and incomplete bladder emptying that result in symptoms of voiding frequencynocturiaand incontinenceand it can lead to serious complications such as permanent bladder and kidney damageAging related UAB may affect almostof Americans overand nearly two thirds of inc ...