Award Data

Cancer immunotherapy, particularly genetically engineered adoptive T cell transfer, has shown great potential for the treatment of cancer patients. The use of T cells engineered to express a specific T cell receptor (TCRs) or chimeric antigen receptor (CARs) to treat cancer has generated durable cures for many cancer patients and has resulted in the first FDA approved CAR-T therapy to treat childh ...

Agilvax’s AX09 is an Immunotherapy for Triple-Negative Breast Cancer: Agilvax is developing cancer immunotherapies and vaccines with its proprietary virus-like-particle (VLP) platform technology. Agilvax’s lead product, AX09, is an immunotherapy for triple-negative breast cancer (TNBC) targeting cancer stem cells (CSC) that is designed for use in combination with existing and emerging therapie ...

This fast track SBIR application submitted by Advanced Medical Electronics Corp. requests funds to develop a software system that helps people living with mild cognitive impairment, Alzheimer’s disease, and other dementia to age in place and give them the choice whether and when to move. Staying at home is both preferred and less expensive, but there are a number of challenges to overcome. The p ...

Project Summary Newinnovative biological materialsthat promote healing and prevent thrombosisare in high demand to improve a variety of extracellular matrixECMproducts ranging from wound dressings to vascular productsConsidering the aging population and a sharp rise in the incidence of diabetes and obesity worldwidethe increase in chronic wound treatment exacerbates this burdenIn the United States ...

The Bumps: A Device for Rapid, Non-Invasive Quantification of Touch Sensation Abstract !Our proposal describes an elegant device called the Bumps that quantifies finger pad touch sensation at low micron levels. The objectives are to diagnose peripheral neuropathy near its onset, when the possibility for reversal is highest, and to monitor either progression or reversal of neuropathy during treatme ...

Project Summary/Abstract We propose the development of a novel balloon angioplasty inflation device for improving the safety and efficacy of balloon angioplasty. Atherosclerosis is associated with coronary artery disease, ischemic stroke and peripheral arterial disease. Percutaneous balloon angioplasty, often in conjunction with stent device deployment, has been associated with prolonged survival, ...

Project Summary Abstract Minnesota HealthSolutions CorporationMHSproposes to develop a child safety seat with a novel intuitive singlestep harness system to improve the rate of proper harnessing of children into child safety seatsChildren are harnessed into child safety seats via apoint harness with shoulder straps that buckle at the crotchThe entire harness assembly must be properly tensioned to ...

Project Summary: With delineation of the pathogenesis of lung diseases, significant advances are being achieved in the pharmaceutical development of therapeutic interventions. New putative drugs are continually being identified; however, their initial availability is often extremely limited, particularly for biologically-based, macromolecule agents (e.g. proteins, genes, RNA, and antibodies). Tran ...

Abstract In this Phase II SBIR project, ASTER Labs will enhance a hands-free automatic oral hygiene device in the form of a comfortable mouthpiece that was designed and successfully tested and evaluated during a Phase I study for persons with oral hygiene disabilities and their caregivers, and then investigate the device’s efficacy in reducing dental plaque and reducing burden, thereby improving ...

This Phase-II SBIR proposal directly addresses the need to improve the size, weight and power, SWaP, of optical cryocoolers. In particular, the proposers will work toward increasing the efficiency of optical cryocoolers by incorporating cooling materials that require less input laser power to achieve a given heat lift. The new cooling materials will be high-purity crystals doped with active rare-e ...