Award Data

PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...

N5 Sensors partnering with George Mason University (GMU) have demonstrated ultra-small, low-power gas sensors, ideally suited for integrated space suit monitoring. A single-chip carbon dioxide (CO2), oxygen (O2), and ammonia (NH3) sensors capable of operating at high-humidity conditions, different range of oxygen in the environment and with low-power consumption was demonstrated as a proof-of-conc ...

Legacy satellite command and control capabilities and their related telemetry operate in a largely stove piped framework. Satellites are still commanded, controlled, and communicated with their ground station in a specific constellation structure. Each ground station is unique to a given constellation and the communications and telemetry are aligned to the specific constellation, underscoring an o ...

DESCRIPTION (provided by applicant): Enabling high dose regional chemotherapy with minimal systemic toxicity Abstract: The primary objective of this proposed study is to develop a filtration system that maximizes the removal (gt90%) of chemotherapeutic agents, such as doxorubicin, from blood while minimizing adverse effects of filtration on blood chemistry and hematological parameters. Vascular V ...

AbstractThe pathogenesis of Sickle cell diseaseSCDcomprises a complex interplay of factors associated with vascular endothelial activationintense inflammationand increased sickle cell adhesionMicrovascular occlusion in SCD is initiated by adhesion of sickle red blood cellsRBCsto the endotheliumleading to acute painful vasoocclusive crisisVOCand the clinical morbidity in SCDTreatment strategies inc ...

The objective of the Phase I proposal is to investigate the application of controlled cavitation cleaning technology in conjunction with gecko-inspired mechanical adhesion and soft elastomeric applicators for use in non-intrusive EOD operations. This investigation requires the proof-of-concept testing and validation of a controlled cavitation cleaning mechanism, and a soft robotic gecko-inspired m ...

Plasma Controls, LLC (SBC) and Colorado State University (RI) will mature an energy and species plasma diagnostic for use with plasma thrusters. The combined Energy and Velocity Analyzer for Distributions of Electric Rockets, or the lsquo;E-VADERrsquo;, is needed especially for characterizing the plasma plume of Hall thrusters, where researchers desire to know ion energies and charged species frac ...

Autonomous systems continue to be outfitted with larger amounts of sensors that are capable of collecting extremely large amounts of data over the course of a mission. Even autonomous systems with high storage capacities can run into storage limitations when burdened with large amounts of sensor data over long mission durations. This proposal will develop a Learning-based Approach for Relevant Dat ...

DESCRIPTION (provided by applicant): The overall goal of this study is to develop a head tracking procedure for the automated assessment of hearing in infants using Visual Reinforcement Audiometry (VRA). The head tracking procedure will be incorporated into the Intelligent Visual Reinforcement Audiometry (IVRA) system from Intelligent Hearing Systems Corp. The IVRA system currently provides automa ...

In Phase I, ISSI will design and demonstrate a laser absorption-based sensor for time-resolved measurements of combustion fuel/product concentrations (H2O, CO, CO2 and fuel) and gas temperature within the detonation channels and nozzle exit-plane of a rotating detonation rocket engine (RDRE). The goal of this STTR is to develop a single sided sensor that plugs into the outer wall of the RDRE simil ...