Award Data

Improved ignition methods are needed for advanced vehicle combustion systems, in particular those that allow reliable ignition of lean mixtures in gasoline engines at elevated pressures. Laser ignition is a candidate technology having the potential to address these needs. However, despite more than 40 years of laser ignition research, the technology is not yet in commercial use. A critical proble ...

While there is no lack of performance counter tools for coarse-grained measurement of cache activity, there is a critical lack of tools for relating data layout to cache behavior to application performance. Generally, any nontrivial optimizations are either not done at all, or are done by hand requiring significant time and expertise. To the best of our knowledge no tool available to users measure ...

There is a need to increase the beam intensity of particle accelerators based on superconducting RF cavities, but detrimental Higher Order Modes (HOMs) generate inside the cavities. HOMs excite the beam and lead to instabilities and particle losses. HOM dampers absorb this RF power and are critical component, but next generation HOM absorber materials are needed to enable increased beam intensitie ...

Electrons play a very key role in plasma chemistry and dynamics of low temperature plasmas. Improved capability for measuring electron number density, ne, and electron energy distribution function, EEDF, in weakly ionized low temperature plasmas would benefit both fundamental study and application areas. For example, the capability would directly benefit emerging research targeted at modifying and ...

Successful adoption of open frameworks such as perfSONAR in Science DMZs within DOE labs, universities, and small-businesses, and the emerging trends of software-defined cloud platforms that inherently require multi-domain performance transparency are major drivers for a new market. However, perfSONAR framework and other proprietary solutions developed by industry cannot be effectively integrated ...

The laser plasma accelerator (LPA) is a very promising technology for generating gamma rays for the detection of contraband bulk nuclear materials, but is currently limited by the rate at which the beam can be pulsed. Erosion of the capillary plasma channel is the main limiting factor and can be mitigated through the use of artificial diamond to construct the channel. Computational modeling and ...

DESCRIPTION (provided by applicant): The long term goal of this project is to develop and commercialize noninvasive equipment, called the sleep and respiratory track (SARTrak) system, for high throughput detection of sleep apnea in animals. The specific goal for the Phase I application is to design and evaluate a basic model of the SARTrak system with eight chambers (one chamber per animal), i.e. ...

DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...

DESCRIPTION (provided by applicant): In the last decade, Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant pathogens in the United States (US) and throughout the world. These infections are increasingly prevalent and highlylethal, killing 50-60% of those infected. Worse, strains of A. baumannii that no known antibiotic will kill have now emerged, and will continue ...

DESCRIPTION (provided by applicant): Up to 170 million people worldwide are chronically infected with HCV Hepatitis C virus (HCV) putting the infected individuals at significant risk for cirrhosis, liver failure and liver cancer. End- stage liver diseasecaused by HCV is the leading indication of liver transplantation (LT) in the United States. However, reinfection with HCV occurs universally and ...