Award Data

DESCRIPTION (provided by applicant): Our proposal describes an elegant device called the Bumps that quantifies touch sensation on the fingers at low micron levels. The objectives are to diagnose peripheral neuropathy near its onset, when the possibility for reversal is highest, and to monitor either progression or reversal of neuropathy during treatment. Target neuropathies are those related to ch ...

Calculations undertaken by physicists for solving fundamental problems such as Lattice Quantum Chromo Dynamics (LQCD) are prohibitively demanding without expertly optimized software. Such software is very complex and costly to write and maintain without automated tools, especially for advanced heterogeneous architectures. PUMA-V provides these automated tools, an optimization and visualization too ...

Due to huge levels of computing parallelism and higher performance per watt, comuting accelerators are crucial for increasing HPC efficiency. This is economically significant for small and medium size manufacturing companies (SMMs) and essential for transition to Exascale computing. However, due to high procurement costs, in-house maintenance of an accelerated HPC cluster is prohibitive for many ...

The feasibility for fusion as a practical energy source needs to be enhanced significantly by removing some of the restrictions that low-temperature superconductors put on the fusion magnet systems. This can be done by using high-temperature superconductors, allowing for much larger temperature margins, a higher magnet performance and less mechanical degradation during operation. There are curren ...

This Small Business Innovation Research (SBIR) Phase I project seeks to address the unmet need for high-throughput, cost-effective research tools to model the metastasis of cancer cells. The proposed research objectives are to (1) discover cost-effective, commercially scalable methods allowing the production of aligned nanofibers in a 96-well plate format and (2) verify that the fiber alignment is ...

DESCRIPTION (provided by applicant): Preeclampsia, a hypertensive disorder of pregnancy, is a leading cause of maternal and neonatal morbidity and mortality around the world, responsible for approximately 76,000 maternal and 500,000 infant deaths per year.As a heterogeneous and poorly understood disorder, its pathogenesis and possible treatments are an area of active research. While the majority o ...

DESCRIPTION (provided by applicant): The broad objective of this proposal is to improve the clinical effectiveness of liver lesion biopsy by fusing respiratory-compensated PET with CT images in the CT suite. On CT imaging alone, localization of liver lesions can potentially be challenging, particularly in selected cases where differentiation of the tumor from adjacent liver parenchyma may be diffi ...

DESCRIPTION (provided by applicant): Validation of computing algorithms has been a challenging topic over the last few years. In fact, several international workshops in the medical imaging field started to involve the community through grand challenges . A grand challenge involves selecting driving biological/scientific problem and asking experts to submit their best results and methods to solve ...

DESCRIPTION (provided by applicant): Image-based evaluation of pathologies over time is complicated by variability in image acquisition and patient positioning, deformations due to respiratory and cardiac motion, and the clinical standard in radiology of comparing unaligned images. This application proposes a computational method for longitudinal image analysis that captures, illustrates and quant ...

DESCRIPTION (provided by applicant): Nearly 1.7 million Americans suffer traumatic brain injury (TBI) annually, which constitutes an important and significant US medical health concern. Although neuroimaging plays an important role in pathology localization and surgical planning, TBI clinical care does not currently take full advantage of neuroimaging computational technology. We propose to develo ...