Award Data

Barrett’s esophagus (BE) is the strongest known risk factor for, and obligate precursor of, esophageal high- grade dysplasia (HGD) and adenocarcinoma (EAC). However, determining future neoplastic progression risk is quite challenging in BE patients: current risk estimation is based solely on highly variable, subjective, observer-dependent histopathologic diagnoses (i.e., non-dysplastic (ND), Low ...

PROJECT SUMMARY During the production of therapeutic biologicals, glycosylation has been identified as a critical quality attribute (CQA) that must be carefully monitored to ensure that the desired protein stability, immunogenicity, antibody effector function, pharmacological safety and potency, and serum half-life are consistently obtained. Many factors can affect the composition of the glycan ch ...

Vivo is a virtual small group exercise program designed for adults 55 and over that is unique in the increasingly popular digital fitness market. Vivo offers 3 key market differentiators: 1) a personalized and individualized live training experience with feedback from a certified trainer, 2) a community of older adult exercisers which enhances motivation and social support, and increase accountabi ...

The Microballoon Manufacturing and Autopilot Development Program proposed under the scope of this effort is a comprehensive initiative focusing on advancing the production process and flight controls of stratospheric microballoons. The program emphasizes

Abstract Out-of-hospital cardiac arrest affects over 350,000 people in the U.S. annually, but only 10.8% survive. Bystander cardiopulmonary resuscitation (CPR) improves survival, but rates of training in the U.S. are low. It is recently required by law in 39 U.S. states that high school students learn CPR. However, current methods of teaching CPR use outdated pedagogical strategies and expensive d ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to develop the first small RNA-based immunization approach for several deadly plant diseases including Xylella fastidiosa (Xf) in grapevines. Xf diseases include (1) Olive Quick Decline Syndrome, which is currently threatening the entire Southern European olive industry and killing trees t ...

Abstract Nytricx is developing a new class of Nitric Oxide (NO)-releasing intravascular medical catheters to combat infection and thrombosis associated with indwelling vascular catheters. NO gas is a natural anti-infective and anti-thrombotic human product principally released from blood vessels and immune cells. Nytricx NO-releasing technology to the catheter surfaces via a polymer matrix, mimics ...

Today, the United States is under constant threat in the cyber domain as Russia and the People's Republic of China (PRC) have penetrated, compromised, and maintained advanced persistent threats (APTs) within US networks and applications. Since these threa

Across the Department of Defense (DoD), there is a need for a standardized, enterprise-driven capability to automatically provision Joint Deployable Kits to support Defensive Cyber Operations (DCO) on United States (US) networks.  These deployable sensors

Internet-based TRAC (i-TRAC): Interactive Emotion Regulation Skills Training to Improve AdolescentSexual Health Adolescence is a critical developmental period during which behavioral patterns are formed that have powerful influences on current and future health. This is particularly true for sexual behavior, which is affected by the biological changes of puberty as well as normative developmental ...