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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Fluorescent IRE sensor for PD drug discovery

    SBC: Lucerna Inc.            Topic: NIA

    SUMMARY Parkinsonandapos s diseasePDis a debilitating neurodegenerative disease that affects aboutof the population over the age ofThe pathological hallmark of PD is the presence of intracellular protein aggregates that cause the degeneration and then death of dopaminergic neurons in the substantia nigraThe presynaptic proteinsynuclein was found to be the main component of Lewy bodies andsynuclein ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Splice sensors for cancer drug discovery

    SBC: Lucerna Inc.            Topic: 102

    SUMMARYRNA splicing plays a central role in the generation of proteome diversity and in gene regulationSplicing impacts vital cellular processessuch as cell fate and differentiationacquisition of tissue identityand organ developmentThusdefects in splicing has been linked to many diseasesincluding spinal muscular atrophyDuchenne muscular dystrophyParkinson s diseaseand several types of cancerRNA sp ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Novel Polymer Matrix for Dental Applications

    SBC: TDA Research, Inc.            Topic: NIDCR

    Project SummaryAbstract Dental caries are the most common childhood disease in the United StatesDental sealants are materials that are applied to the pits and fissures of healthy teeth to prevent dental caries or other forms of decayThis method prevents bacteria ingress and acid dissolution and targets the portions of the tooth surface whereof the decay developsSealants are safe and effective in p ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Large-aperture Electrically Tunable Lenses with 40 Microsecond Hysteresis-free response for Remote Focusing

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 101

    PROJECT SUMMARY This Phase II Lab to Marketplace proposal aims to commercialize a new remote focusing technique that can change the focus of a microscope by as much asm in less thansorders of magnitude faster than other discrete focus change techniquesOur initial market is neuroscience imagingwhere the ability of researchers to step between focal planes at the millisecond timescale of neuronal cir ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Development of Ryan Companion Robot for Assisting Elderly People with Alzheimer's Disease

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed Fast Track SBIR effort is to develop and commercialize the Ryan CompanionBothereafterRyanan intelligent conversational life like social robotdesigned to improve the well being and quality of life of older adults with early stage Alzheimerandapos s diseaseADand AD Related DementiaADRDAccording to the NIAresearch reports estimate that as many asmillion Americans may hav ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Caminamos: A location-based Smartphone App for Latinas to Connect with Nearby Walking Partners

    SBC: KLEIN BUENDEL, INC            Topic: 102

    Health disparities are high among LatinasThey are more likely to be overweightdiagnosed with diabetesand physically inactive compared to their non Hispanic White counterpartsThusinterventions that target improving health access and ameliorating chronic diseases among Latinas are of high public health importanceAvailable data suggest that community focused interventions produce improvements in phys ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. FMRI Dynamic Phantom for Improved Detection of Resting-State Brain Networks

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: NIDA

    Abstract Functional magnetic resonance imagingfMRIhas rapidly become the dominant tool in human neuroscience researchand is poised to become a transformative technology in the areas of psychiatric and neurological diagnosticsIn recent yearslarge scale$M $B USDand long termyearinternational investmentse gNIDA Adolescent Brain Cognitive Development StudyNIH Human Connectome ProjectWhite House BRAIN ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Noom Coach for Bariatric Surgery

    SBC: Noom, Inc.            Topic: 300

    Overweight and obesity have reached epidemic proportions in the United StatesAs few behavioral treatments are effective for weight lossbariatric surgery is an increasingly important optionAlthough these procedures are more helpful than psychosocial treatmentspost operative weight losses vary widely and a notable subset of patients demonstrate suboptimal weight loss or substantial weight regainAdhe ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. A novel device and rescue solution for the improved post-thaw viability and function of human stem cells used in cell therapy.

    SBC: CELL PRESERVATION SERVICES INC            Topic: 400

    There are overhuman stem cell trials currently underway worldwideMost of these trials use adipose derived mesenchymal stem cellsadMSCswhile others use differentiated human embryonic stem cellshESCsWhile human induced pluripotent stem cellsiPSCsare currently in limited trials in select countriesthe future promise of these cells for treating disease worldwide is indisputable and their increasing use ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Development of a scalable, portable fMRI-validated device platform for acute musculoskeletal pain.

    SBC: WAVi Co.            Topic: NIDA

    Pain assessment is a pressing clinical problem in need of better measurement toolsProposedsolutions include electroencephalography and event related potentialsEEG ERPautonomic measuressuch as heart rate and heart rate variabilityand analysis of facial expressionsAll of thesepromising modalities could potentially combine into one streamlined test by establishing theprotocols that give the highest i ...

    SBIR Phase I 2018 Department of Health and Human Services

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