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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A high-throughput platform for neo-antigen based cancer immunotherapy

    SBC: ImmuDX LLC            Topic: 100

    Abstract Critical to the future progress of cancer immunotherapies is the discovery and tracking of T cells specific for cancer cells but not normal tissuesNeo antigen derived from mutations are a group of attractive antigens for cancer immunotherapyBecause they are mutated variants of self antigensthey are immunologically considered as foreign antigens and are not part of the self antigensThusthe ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY GlioblastomaGBMis an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomideTMZEfforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brainIn contrastsensitizing GBM to TMZ is an appealing strategy because TMZ has excelle ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Preclinical evaluation of co-delivery of TNF-alpha siRNA and a glucocorticoid for rheumatoid arthritis

    SBC: Via Therapeutics, LLC            Topic: NIAMS

    Rheumatoid arthritisRAis a chronic inflammatory disease that manifests as painful and swollen joints and subcutaneous nodulesamong other symptomsThe pathophysiology of the disease is autoimmune in nature and is believed to arise from genetic susceptibility coupled with specific environmental exposuresIn RAthe synovium is the primary site of inflammationsynovial macrophages increase significantly i ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. 3D Biomimetic Platforms to Model Kidney Cell Biology for In Vitro Toxicity Screening

    SBC: PROBETEX INC            Topic: NIEHS

    SUMMARY A large variety of chemicals require evaluation for organ specific toxicityAnimals have traditionally been used for toxicological screeninghowever this mode of evaluation is expensiveethically challenged and not always predictableIn vitro monolayer has been used as an alternativehowever cells in this format lose the specialized interactions requisite for differentiation and optimal functio ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Improved Esophageal Safety in Atrial Fibrillation Elimination

    SBC: Biotex, Inc.            Topic: NHLBI

    Project Summary The overall goal of this SBIR proposal is to develop a novel device to allow easier atrial fibrillationAFablation procedures by mitigating risks for esophageal injuryAtrial fibrillation is the most common chronic disease of heart rhythmand can be treated with application of radiofrequency energy or cryo to ablate susceptible portions of the endocardial surface of the pulmonary vein ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Targeted Nanotherapy to Donor Organ Endothelia Modulates Early Immune Responses and Protects Against Late Graft Failure

    SBC: ToleRaM NanoTech LLC            Topic: NIBIB

    ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Novel Composite Dressing for Oxygen Transport in Exudating Wounds


    SUMMARY Chronic wounds are a significant health problemcases of which are increasing due to rising numbers of diabetic patientsan upsurge in obesityan increase in cardiovascular diseaseand an aging of the population in the USAEuropeJapanand ChinaClinical characteristics of chronic wounds are that they are hypoxichave low oxygen levelswhich hinders the healing processand are moderately to highly ex ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Construction and testing of a rabbit cornea-equivalent for evaluation of chemical injury in vitro


    ABSTRACTWe propose combination of the rabbit cornea endothelial and epithelial cells with bioengineered scaffolds in cell culture well insertsThis technology could significantly reduce the use of rabbits for the Draize rabbit eye irritation assayThe barrier to commercialization is the lack of an effective method for storingbankingof living bioengineered cornea equivalentsWe will combine cell expan ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: R

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Continuous removal/disposal system for the concurrent sorption and breakdown of contaminants into harmless precipitates

    SBC: Lynntech Inc.            Topic: NIEHS

    PROJECT SUMMARYThere is an ever growing need for useable uncontaminated water in the United States and across the globeThis increasing need includes many uses with the most significant being for potable waterHowevera significant problem is occurring at the confluence of industry and consumer that continues to put access to clean drinkable water at riskindustriesincluding oilmanufacturingagricultur ...

    SBIR Phase I 2018 Department of Health and Human Services

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