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A Systematic Medical Approach to Reward Transformation SMART for Brain Health in Opioid Use DisorderSBC: Versa Integrated Solutions, Inc. Topic: 102
Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: WinSanTor, Inc. Topic: 101
PROJECT SUMMARY Over million people worldwide including million people in the USA are HIV positive HIV associated sensory neuropathy HIV SN is the most frequent neurological manifestation of HIV and is characterized as a distal symmetrical predominantly sensory polyneuropathy HIV SN may represent clinically indistinguishable neuropathies with distinct pathogenesis a distal axona ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of nanoscale confocal photothermal IR micro spectroscopy n CPIRSBC: Anasys Instruments Corp. Topic: 100
Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Epigen Biosciences, Inc. Topic: 101
PROJECT SUMMARY Fragile X syndromeFXSis the most common inheritable form of cognitive impairment and the leading known genetic cause of autismFXS is caused by the loss of expression of the fragile X mental retardation proteinFMRPA major challenge for FXS research is to develop treatment strategies that improve the intellectual capabilities of patientsDysregulated protein synthesis is widely accept ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Enabling point-of-care molecular diagnostics by developing an adaptive PCR instrument and on-demand kit reagentsSBC: BIOVENTURES, INC Topic: 172
Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
Polyionic Papillomavirus like Particles VLP for the Treatment of HPV oropharyngeal squamous cell carcinomas OPCsSBC: PATHOVAX LLC Topic: 102
The broader impact commercial potential of PathoVax s STTR phase I proposal is to improve outcomes of cancer immuno therapy utilizing a vaccine formulation combining an immunogenic chimeric virus like particle cVLP vaccine with FDA approved immune check point inhibitors PathoVax proposes to develop this technology for treatment of human papillomavirus HPV associated cancers However cancer ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: VioMedix, LLC Topic: 102
PROJECT SUMMARYABSTRACTBreast cancer is the second leading cause of death in females with cancerInapproximatelynew cases of invasive breast cancer were diagnosedwhere an estimate ofwas expected to succumb to their diseaseIt is estimated that one in eight women will develop breast cancer in their lifetimeBreast cancer is classified into subtypes based on the expression of estrogen receptorERprogest ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Cavatar LLC Topic: 102
Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Surface Bioadvances, Inc. Topic: NIAMS
Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOVINC, LLC Topic: NIDCR
ABSTRACT Dental implants are a central part of modern dental practice with the overall market for replacement and reconstruction of teeth expected to reach over $billion in the next several yearsIt is estimated that overmillion people in the United States are missing all of the teeth in one or both of their jaws leading to lower quality of lifeMost of these implants will be successful for long ter ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health