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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growth

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NICHD

    There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Brillouin optical eye scanner prototypes for commercialization

    SBC: INTELON OPTICS, INC.            Topic: N

    ABSTRACT The overall goal of this STTR project is to commercialize a novel optical eye scanner device capable of measuring the biomechanical properties of tissues via Brillouin light scatteringThe Brillouin technology invented in the co PI s lab has shown broad potential for improving the diagnosis and treatment of vision disordersClinical data obtained with current laboratory systems revealed cor ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Automated preparation of single-cells and nuclei from solid tissues

    SBC: S2 GENOMICS, INC            Topic: 172

    Project Summary AbstractThis project designsdevelopsand automates a novel system to process solid tissue into single cellssingle nucleiand high molecular weight DNA using disposable cartridges without user interventionThe system will support downstream single cell RNA or DNA sequencingsingle nuclei RNA or DNA sequencingand long read sequencers and optical mappingThe long term goal of the project i ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Advancing Formulation of STING agonist for Universal Flu Vaccine

    SBC: IMMvention Therapeutix, Inc.            Topic: NIAID

    Summary Influenza virusa member of the orthomyxovirus familyhas three different types that infect humansABand CTypes A and B produce annual epidemicsand type A influenzawhich resides asymptomatically in birdscan cause pandemic infections in humansIn addition to common flu like symptomse gfeverchillsmalaisemuscle painin susceptible populations influenza can induce potentially fatal secondary compli ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Amelioration of rhinovirus induced asthma exacerbations by serpin B1

    SBC: SERPLUS TECHNOLOGY LLC            Topic: NIAID

    PROJECT SUMMARY Asthma exacerbations are a major cause of ER visits and hospitalizations with annual direct costs of approximately $billionyear in the USAViral infectionsin particular rhinoviralRVinfectionsare a major precipitant of asthma exacerbations in allergic asthmaticsAs there are overRV serotypes andfor nowno RV vaccinenovel strategies to inhibit RV induced airway inflammation are needed t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Technology for Non-invasive High-throughput Breath Tracking in Rodents

    SBC: SIGNAL SOLUTIONS LLC            Topic: NHLBI

    ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health conditions including respiratory depression due to disease or drug useand other s ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Expansion of Immuno-CometChip Platform

    SBC: AMELIA TECHNOLOGIES LLC            Topic: NIEHS

    Project SummaryThe objective of this supplementation request is to further our recent advances in the development of thewell Immuno CometChip assay results and build a prototypewell preformer giving the assay more utility and increasing commercial viability

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Intravascular molecular-structural NIRF-IVUS imaging of coronary artery disease

    SBC: IntraVascular Imaging, Inc.            Topic: NHLBI

    The goal of this Phase I STTR project is to constructoptimizeand test a clinically viable intravascular near infrared fluorescence intravascular ultrasoundNIRF IVUSimaging catheter for simultaneous molecular and structural diagnosis of coronary artery diseaseCADCAD is a worldwide leading cause of death and disabilityincluding acute myocardial infarctioncongestive heart failureand sudden cardiac de ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. PAR2 Pepducins as a Novel Treatment of Idiopathic Pulmonary Fibrosis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NHLBI

    Idiopathic pulmonary fibrosisIPFthe most common of the interstitial lung diseasesoccurs in aboutpeoplewithnew cases diagnosed annually in the USThe typical clinical course is a progressive fibrotic disease characterized by scarring and `honeycombingandaposof the lungs causing an irreversible loss of the tissueandapos s ability to transport oxygenCo morbid pulmonary hypertension is commonly seen in ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Chronic intrapulmonary delivery of a novel small molecule Wnt/beta-catenin inhibitor for Idiopathic Pulmonary Fibrosis

    SBC: BETA CAT PHARMACEUTICALS, INC.            Topic: NHLBI

    Project Summary Idiopathic pulmonary fibrosisIPFis a devastatingprogressive disease with no known cure and no treatment that convincingly alters the disease course or significantly improves mortalityThe objective of this proposal is the development of nebulized delivery of the small molecule inhibitor of Wntcatenin signalingBCfor Idiopathic Pulmonary FibrosisPre clinical studies in rodentsdogsand ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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