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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
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Chronic intrapulmonary delivery of a novel small molecule Wnt/beta-catenin inhibitor for Idiopathic Pulmonary FibrosisSBC: BETA CAT PHARMACEUTICALS, INC. Topic: NHLBI
Project Summary Idiopathic pulmonary fibrosisIPFis a devastatingprogressive disease with no known cure and no treatment that convincingly alters the disease course or significantly improves mortalityThe objective of this proposal is the development of nebulized delivery of the small molecule inhibitor of Wntcatenin signalingBCfor Idiopathic Pulmonary FibrosisPre clinical studies in rodentsdogsand ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NEONC TECHNOLOGIES INC Topic: 102
Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AEON IMAGING LLC Topic: W
Summary Recentlywe found extensive remodeling of the microvasculature of the retinaoccurring in some diabetic patients much earlier than expectedThis provides the potential for novel biomarkers to improve classification of patients for management and cost effective testing of therapiesHoweverthe equipment is too expensive for most clinics and small practicesThese early retinal microvascular change ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ASPIREBIO CORP Topic: 101
PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: KS & ASSOCIATES LLC Topic: NCATS
PROJECT SUMMARY Chemical risk assessment has been widely applied in chemical industry as a necessary step to get new commercial chemicals registeredand in governmental agencies as a critical procedure to evaluate the toxicity of chemicals in order to properly regulate them to protect human health and the environmentThe Lautenberg Chemical Safety Act further strengthens the importance of chemical r ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's diseaseSBC: NEURODON, LLC Topic: NIA
Alzheimer s diseaseADis an immense national public health burdenIt is theth leading cause of death in the US with overmillion Americans sufferingand costs of over $billion in health care and related expensesThis patient population is expected to almost triple over the nextyearsDespite this urgent needthere are currently no disease modifying agents approvedNeuron loss is the only physiological phen ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ELECTRONUCLEICS INC Topic: NIAID
Project Summary This project is focused on feasibility testing of a new device based on electromechanical signal transduction for the low cost$in electronicsoptics free and amplification freee gno PCRdetection of DNA RNA at ultralow concentrationThe device addresses the projected $B disease diagnostics market and is well suited for the detection of bacterial pathogens in body fluidsfood and water ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviorsSBC: WEINBERG MEDICAL PHYSICS, INC. Topic: NIDA
Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: INTELLIGENT FIBER OPTIC SYSTEMS CORP Topic: NINDS
Sonomyographic Control of Fiber Optically Sensorized Prosthetic Fingers for Graded Force Actuation Intelligent Fiber Optic Systems CorporationIFOSCalle del MundoSanta ClaraCAwww ifos com PROJECT SUMMARY ABSTRACTMAXIMUMLINESIn this Phase I SBIR applicationIFOS and George Mason UniversityGMUpropose an innovative control system leveraging on two emerging technologiesultrasonic imaging based readout o ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: RITHIM BIOLOGICS INC Topic: NCATS
ABSTRACT Atrial fibrillationAFis the most common rhythm disturbance in the US and other developed countriesAF significantly affects the lives of the afflictedcausing symptoms that range from palpitations to fatigueweakness and activity intoleranceand substantially increasing the risks of strokecongestive heart failure and deathThe impact on public health is substantialwith more thanhospital admiss ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health