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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. VesiVax Peanut Allergy Immunotherapy

    SBC: Molecular Express Inc            Topic: NIAID

    Project Summary The current standard of care for peanut allergy is strict avoidance of peanuts Due to the contamination of various food items with peanut protein allergens complete avoidance is difficult to achieve and reduces the quality of life in allergic individuals for fear of accidental ingestion Upon accidental exposure allergic individuals must quickly self administer or receive epine ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Specific Detection of Antibodies to Emerging and Established Arboviruses Including Zika Virus

    SBC: ImmPORT Therapeutics Inc dba Antigen Discovery Inc            Topic: NIAID

    Abstract Zika virus ZIKV infection is currently an epidemic in the western hemisphere It is a WHO declared Public Health Emergency of International Concern since February due to the association of ZIKV infection with microcephaly and other neurologic abnormalities in babies infected in utero and with Guillain Barre syndrome in infected adults An estimated four mill ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Cell free Expression of Cryptic Actinomycetes Gene Clusters for Natural Products Discovery

    SBC: SYNVITROBIO INC            Topic: R

    Project Summary Microbial natural products are known to be rich resources for the search of drug candidates Advances in next generation sequencing have exponentially increased the metagenomic data available from actinomycetes which are known to be prolific producers of bioactive secondary metabolites However much of natural product chemical diversity has not been explored using traditional cu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Biosynthesis of novel and natural plant alkaloid compounds for drug production and discovery

    SBC: Antheia, Inc.            Topic: R

    Abstract Plants produce an exceptional diversity and number of natural products many of which are unique to the plant kingdom However the difficulties in sourcing medicinal compounds from native plant hosts in sufficient quantity and diversity present a critical barrier to supplying existing medicines identifying new drug candidates and progressing through the path to FDA approved pharmaceu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Improved pulse oximetry performance using transmission optical flowmetry

    SBC: Laser Associated Sciences            Topic: 300

    Project Summary Since its commercial introduction in pulse oximetry has become a widely adopted standard of care in operating rooms intensive care units and hospital wards The ability to measure arterial oxygen saturation using pulse oximetry is so useful that it is considered the th vital sign Despite their ubiquity pulse oximeters have suffered from two fundamental limitations sin ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Micromolded Digital Nucleic Acid Test Consumable

    SBC: Combinati Incorporated            Topic: 172

    Abstract For the Phase SBIR project COMBiNATi will prove the feasibility of an array digital PCR adPCR consumable using copy number variation CNV analysis as the application Digital PCR dPCR technology has drawn attentions in both genomic research and clinical research communities for its ability to detect rare events high sensitivity less prone to inhibition high specificity quan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Rock Steady A mobile gamified vestibular rehabilitation therapy app for older adults with complaints of dizziness

    SBC: BLUE MARBLE REHAB INC.            Topic: NIDCD

    Project Summary The long term objective of this SBIR application is to develop and test a minimum viable product MVP of Rock Steady a software application for adults with vestibular dysfunction This product is relevant to the mission of the NIDCD because it addresses the request for the development of technologies for the study diagnosis and treatment of balance disorders particularly for ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Microbial biosynthesis of opioid antagonists a novel low cost method for producing addiction pharmacotherapies

    SBC: Antheia, Inc.            Topic: NIDA

    Abstract Medicinal opioids are essential medicines for treating pain but exhibit addictive properties The United States has committed significant resources to curb opioid dependence and overdose The nal opioids a suite of antagonist and mixed partial agonist opioids are an important group of pharmacotherapies used in drug addicted patients for treating overdose managing symptoms during det ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Wireless Technology for Long Term Non Invasive O Sensing within Cell Encapsulation Devices in Vivo

    SBC: PROFUSA, INC.            Topic: 200

    Summary Islet cell transplantation is an alternative therapy for the treatment of diabetes but requires the administration of immunosuppressive drugs to avoid host rejection Immunoisolation devices such as TheraCyte device protect islet cells from the host response and thus eliminate the need for immunosuppressive drugs However once implanted hypoxic conditions around and within the device res ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Realistic Adaptive Immersive Learning System RAILS for HAZMAT Site Monitoring Characterization and Remediation Training

    SBC: Spectral Labs Incorporated            Topic: 142

    Project Summary The work proposed aims to develop an immersive videogame based training program to train HAZMAT workers specifically involved in the emergency response site characterization waste removal and site remediation at the extensively contaminated sites on the National Priorities List Specific training will be designed to meet the mandates of CFR for HAZWOPER training req ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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