Award Data

PROJECT SUMMARY/ABSTRACT Diabetes Mellitus (DM), a metabolic disorder characterized by defective insulin signaling and elevated blood glucose, has become a public health epidemic with half of the US population diagnosed with either DM or pre- diabetes. One of the most common and devastating sequelae of uncontrolled DM is the development of chronic non-healing wounds. An estimated 25% of diabetic p ...

Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD Project Summary Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are complex diseases that result from many diverse genetic etiologies. Although therapeutic strategies that target specific causal mutations (e.g. C9ORF72 antisense oligonucleotides (ASOs)) may prove effective against individual forms of AL ...

Abstract. Natural products offer excellent sources of health-promoting medicines yet challenges in efficiently and economically sourcing these value-add bio-compounds have prevented their greater availability and promotion to public health. We address this problem by developing a novel image-based screening technology that offers highly sensitive, phenotypic bioassays of metabolite concentrations ...

Abstract. Virtually all optical microscopes for biological imaging are based on refractive objective lenses. The performance of these lenses approaches the theoretical limit, however, their use is limited to the visible to near-infrared spectral range. Even within this range, their performance is only guaranteed over a relatively narrow range, and broadband use is invariably affected by chromatic ...

Project Summary Minimally invasive cardio-thoracic approaches, such as transcatheter aortic valve replacement (TAVR), have recently overtaken traditional surgical methods due to significant reductions in procedural mortality, morbidity, and improved time to recovery. Transfemoral access of the heart via the femoral artery is the most common approach for delivery of large bore devices such as heart ...

Project Summary / Abstract Periodontal disease (PD) is globally the most common chronic inflammatory disease in humans, which according to the Centers for Disease Control and Prevention (CDC) affect 47% of U.S. adults 30 years of age or older and rt60% of those over 65 years.1 Given that the course of PD is marked by a discontinuous pattern of disease activity and inactivity showing exacerbation a ...

Mucormycosis, caused by Mucorales fungi, is a life-threatening infection that occurs in patients immunocom- promised by diabetic ketoacidosis, neutropenia, corticosteroid use, and/or increased serum iron. Because of the rising prevalence of mucormycosis risk factors, the incidence of the infection has risen. The increased number of mucormycosis cases is highlighted by the recent epidemic seen amon ...

Stroke is the leading cause of death and disability worldwide with the strongest disparity instrokes seen in Black middle-aged persons. Black persons have incidence rates of ischemicstroke that are 2- to 3-fold higher than Whites. Additionally, over 80% of stroke survivors willhave immediate and persistent weakness of their upper limb, leaving half of the persons with achronic disability and inabi ...

PROJECT SUMMARY/ABSTRACT This SBIR Fast-Track project will develop a novel mobile health framework for left ventricular end diastolic pressure diagnostics and monitoring, using an innovative, non-invasive cardiac biosensor. Heart disease is the leading cause of death for men and women accounting for more than one-third (33.6%) of all U.S. deaths. The total costs associated with cardiovascular dise ...

Project Summary/Abstract: Due to decreased mobility, deterioration in activities of daily living, and neurological decline that contributes to loss of bladder control, incontinence is a leading comorbidity for those individuals suffering from Alzheimer’s disease and related dementias (ADRD). Further, individuals with incontinence are susceptible to the development of pressure ulcers (PUs), with ...