Award Data

Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia (IDA). Women undergoing basic military training are particularly susceptible to reduced and depleted iron stores. To-date, there are no point-of-care (POC) instruments for comprehensive, accurate determination of iron status. ...

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometricmeasurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed softwareapp aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D imag ...

Defense Health Program (DHP) seeks to develop a new and innovative point of injury device to manage patients with moderate-to-severe Traumatic Brain Injury (TBI). Critical Innovations, NeoMatRx, and KARA & Associates, with consultants Captain David Plurad, MD, FACS (USN, Ret.) and neurosurgeon Michael Levy, MD, PhD., have formed a team of medical device, trauma, and neurosurgical experts to addres ...

Combat soldiers are exposed to vast numbers of dangerous chemicals with potentially adverse health outcomes. This SBIR proposal aims to develop a new class of saliva based diagnostic assays that will measure the bodys response to toxic chemical exposure with a panel of clinically validated biomarkers that are indicative of organ injury. The tests will leverage the proven functionality of lateral ...

There has been considerable interest in the development of alternative therapies for pain management that are neither opioid nor non-steroidal anti-inflammatory drugs (NSAIDs). Kalyra Pharmaceuticals has demonstrated that acetaminophen, also known as APAP

DoD requires a single, multiplexed, saliva-based diagnostic bioassay to determine multiorgan injury-relevant systemic toxicity. This assay should quantitatively-detect clinically relevant biomarkers in saliva and validate organ injury arising from chemical/xenobiotic exposure. Innosense LLC (ISL) is building on its proprietary carbon nanotube platform to construct Nano-Mos for detecting salivary b ...

A key bottleneck to be addressed in regenerative medicine is hypothermic preservation of cells and tissues, which has been shown to extend survival of cell and tissue-based therapies by decreasing ischemic effect. However, preservation technology is aged, toxic and less effective than desired with typical cell survival post-thaw below 50% and unreliable potency. Current technology greatly hinders ...

Trauma is the most common cause of death in ages 1-48. Uncontrolled hemorrhage in the torso is the leading cause of preventable death in military combatants and civilian trauma patients with otherwise survivable injuries. The prospects for survival from hemorrhage-induced traumatic cardiac arrest (HiTCA) are dismal with only about a 1% survival rate. Advances in endovascular technologies have led ...

Complete human anatomy avatars have a broad future role in advanced training environments, providing, for example, medically correct immersive experiences, performance-related physiological modeling studies, and in simulations for the purpose of designing protective armor. USARIEM have created individualized avatars as 3-D tetrahedral Finite Element (FE) meshes with full labeled anatomy, fitted to ...

In order to meet the Defense Health Agencys need for addressing the prevention of secondary brain injury from moderate, severe and penetrating traumatic brain injury (TBI), ChromoLogic proposes to develop a cerebral trauma recovery (CereTRec) drug delivery system. In particular, CereTRec aims to treat TBI during prolonged field care (PFC) to stabilize casualties who sustain a moderate-severe TBI. ...