Award Data

AN ADVANCED PET DATA ACQUISITION SYSTEM IS PLANNED THAT TAKES ADVANTAGE OF RECENT DEVELOPMENTS IN REAL-TIME SOFTWARE, INTEGRATED CIRCUITS, AND CPU DESIGN TO INCREASE PATIENT THROUGHPUT AND TO IMPROVE IMAGE QUALITY AND QUANTITATION. SHIFTING SINOGRAM CORRECTIONS FROM POSTACQUISTION SOFTWARE TO REAL-TIME HARDWARE WILL ALLOW THE CORRECTION OF EVENT DATA ON AN EVENT-BY-EVENT BASIS BEFORE THEY ARE LUMP ...

THIS PROJECT WILL FACILITATE THE DEVELOPMENT OF A POWERFUL, ULTRA-HIGH-RESOLUTION WHOLE-BODY POSITRON EMISSION TOMOGRAPHIC (PET) SCANNER, WHICH IS ENVISIONED TO HAVE 2.5-MM IN-PLANE RESOLUTION, 7.5-MM AXIAL RESOLUTION, A 16-CM AXIAL FIELD OF VIEW, 3-DIMENSIONAL VOLUME SAMPLING, AND A SYSTEM SENSITIVITY OF AT LEAST 200,000 COUNTS/SEC/MICROCI/CC. AN IMAGING SYSTEM OF THIS TYPE WILL HAVE IMPROVED CLI ...

SummarySystemic lupus erythematosusSLEor lupus is an autoimmune disease that impacts more thanmillion people worldwideincludingmillion AmericansNearlyof these patients will develop lupus nephritiswhich can cause kidney failureAs a resultits financial burden to individual patient can reach $yearmuch higher than many other diseases because of kidney transplantationAlthough early treatment of lupus n ...

DESCRIPTION (provided by applicant): The objective of TruTouch Technologies, Inc. is to develop a new, more accurate, and cost-effective technology for noninvasive measurement of alcohol in human subjects. The TruTouch noninvasive measurement device offers the promise of reduced measurement time, elimination of safety concerns regarding handling of bodily fluids, and simplification of the alcohol ...

AbstractPartial nephrectomy is becoming an increasingly important treatment for kidney cancer because more than 60% of kidney cancer cases are diagnosed in early, localized stages. Compared to radical nephrectomy, partial nephrectomy offers much better preservation of renal function while having an equivalent oncological efficacy for the localized kidney cancer, thereby significantly reducing the ...

AbstractPartial nephrectomy is becoming an increasingly important treatment for kidney cancer because more than 60% of kidney cancer cases are diagnosed in early, localized stages. Compared to radical nephrectomy, partial nephrectomy offers much better preservation of renal function while having an equivalent oncological efficacy for the localized kidney cancer, thereby significantly reducing the ...

DESCRIPTION (provided by applicant): Probably the most versatile assay for genomic scale research is the high-density microarray. Microarray analysis has the potential for uncovering the complex behavior of gene expression. Microarray trends are becoming established which includes higher throughput and a need to analyze pg quantities of mRNA. This proposal is focused on one aspect of microarray te ...

DESCRIPTION (provided by applicant): Probably the most versatile assay for genomic scale research is the high-density microarray. Microarray analysis has the potential for uncovering the complex behavior of gene expression. Microarray trends are becoming established which includes higher throughput and a need to analyze pg quantities of mRNA. This proposal is focused on one aspect of microarray te ...

Project SummaryLung cancer (LC) with over 2 million cases/year worldwide also remains the leading cause of cancer- related death in the US and Europe. Treating LC remains challenging due to ~60% of patients presenting with Stage IV disease, the heterogeneity of tumors with respect to genetic and epigenetic mechanisms that alter gene expression, and treatment-related resistance. Combining chemother ...

AbstractObstructive sleep apnea (OSA) during pregnancy is associated with increased risk of developing gestational diabetes, hypertension, preeclampsia, and eclampsia, contributing to maternal and neonatal morbidity and mortality. Furthermore, OSA increases risk of chronic cardiovascular disease, well beyond pregnancy, raising the stakes for detection and management during pregnancy. Research stud ...