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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Inhalational A Apolipoprotein A Mimetic Peptide for the Treatment of Asthma

    SBC: Technology Holding, LLC            Topic: NHLBI

    SummaryNew treatments are needed for severe asthmatics who do not respond to standard therapy with inhaled steroids especially those with a type low phenotype such as individuals with neutrophil predominant inflammation This solicitation is for the development and early commercialization of an inhalational formulation of the A apolipoprotein A I apoA I mimetic peptide that can be adminis ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. HQ-55 VTOL UAS for Ship Based Operation

    SBC: L3 Latitude, LLC            Topic: 832

    The Hybrid Quadrotor concept, developed by Latitude Engineering, combines the high power density of electric motors and propellers with the high energy density of a piston engine and liquid fuel. Together, each technology enables maximum performance in HQ's two regimes of flight: the electric system is responsible for lift while hovering (high power, short endurance), and the gas engine gives long ...

    SBIR Phase I 2017 Department of CommerceNational Oceanic and Atmospheric Administration
  3. High Stability Atmospheric Carbon Dioxide and Methane Analyzer

    SBC: LI-COR, Inc.            Topic: 832D

    LI-COR proposes to continue development of a next-generation CO2/CH4/H2O analyzer that will offer an unprecedented combination of high precision and stability, making it the first highperformance gas analyzer suitable for long-term unattended operation. The instrument will be smaller, lighter, and far less expensive than competing technologies. LI-COR’s approach exploits a proprietary, revolutio ...

    SBIR Phase II 2017 Department of CommerceNational Oceanic and Atmospheric Administration
  4. A Platform for Safe Noninvasive Prenatal Genetic Testing at Five Weeks of Pregnancy

    SBC: Cradle Genomics, Inc.            Topic: NICHD

    SUMMARY The overall goal of this research is to provide a flexible prenatal genetic testing kit that can be expanded to detect any inheritable trait as early as and up to weeks of gestation from a safe noninvasive Pap smear Studies show that perinatal Pap tests pose no risk to mother or fetus and capture trophoblast like cells that migrate from the placenta into the reproduct ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Natural product inspired antibacterials with unique ribosomal binding

    SBC: Curza Global, LLC            Topic: NIAID

    Project Summary The long term objective of this project is to develop a new class of broad spectrum antibiotics focused on Gram negative bacteria Inspired by a natural product this class targets an unexploited binding site of the bacterial ribosome With ever increasing reports of resistance to frontline therapies addressing Gram negatives there is a critical need for new therapies yet very ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Trypanocidal Compounds for the Treatment of Stage and HAT

    SBC: MEDISYNERGICS, LLC            Topic: R

    DESCRIPTION provided by applicant Human African Trypanosomiasis HAT is a disease caused by a parasitic organism trypanosoma brucei It is often referred to as andquot sleeping sicknessandquot because of the symptoms that emerge in Stage patients The disease exists in two forms depending on the causative parasite Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense T b gamb ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Goldmann Contact Tonometry with Optimized Error Correction

    SBC: INTUOR TECHNOLOGIES LLC            Topic: N

    DESCRIPTION provided by applicant Intraocular pressure IOP is arguably the second most important criteria used to assess visual acuity when eye care professionals are diagnosing treating and managing patients The patented Intuor Applanation Tonometer IAT prism design is a novel and simple approach for improving the accuracy of IOP measurement in the eye The proposal describes an inexpen ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Improving vaccine development through high throughput immunogenicity screening

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract Vaccines are fundamental in preventing debilitating illnesses and saving millions of lives each year But despite these vaccine oriented victories infectious diseases are still the second leading cause of death as well as the leading cause of disability adjusted life years worldwide About six million deaths were attributed to AIDS malaria and tuberculosis in regions where no vaccine ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Androgen Receptor Degraders to Treat Castration Resistant Prostate Cancer

    SBC: Arvinas, Inc            Topic: 102

    DESCRIPTION provided by applicant The overall aim of this grant is to generate data to understand and enable the development of a novel therapeutic approach for the treatment of patients with castration resistant prostate cancer Prostate cancer is the third most lethal cancer in the US with new cases and deaths projected to occur in While early detection surgery and horm ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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