Award Data

DESCRIPTION (provided by applicant): The long-range goal of this research project is to develop a novel and effective strategy for transduction of human dendritic cells (DC) for the purposes of genetic anti-tumor immunization. To accomplish this goal, we will develop an adenovirus(Ad)-based gene delivery system capable of efficient and specific transduction of DC ...

DESCRIPTION (Adapted from the application): The investigators believe the fentanyl transdermal patch currently available has several limitations including the requirement of a long time to reach peak effect and that it cannot be used to treat breakthrough pain (short-lasting episodes of increased pain). ZARs' preliminary data, using its patented controlled ...

DESCRIPTION (Provided by Applicant): An investigation is proposed exploring the use of biochemical reagents to improve fatigue resistance of intervertebral disc tissue. While not well quantified, the capacity of spinal tissue to withstand repetitive loading is a critically important factor in the progression of spinal osteoarthritis. Current treatments for ...

DESCRIPTION (Verbatim from the Applicant's Abstract): Despite the widespread success and enthusiasm f single and double lung transplantation, demand for donor lungs has steadily outgrown supply. Currently, the average wait is two years, with 30 percent wait-list mortality. A prototype Paracorporeal Artificial Lung (PAL) was designed and built by MC3 (Ann Arb ...

DESCRIPTION (provided by applicant): Androgen blockage therapy may relieve the symptom of an advanced, localized prostate tumor; however, once the tumor evolves into a hormone-refractory stage, there is no effective treatment. A continuous activation of AR by antiandrogens (used in androgen blockage therapy) or other "nonconventional" agonists may contribute to prostate cancer progression in patie ...

DESCRIPTION (provided by applicant) This project will develop an artificial intelligence to provide the core functionality for virtual reality and computer based treatments for anxiety disorders. The use of artificial intelligence offers a number of advantages over existing treatments: (1) artificial intelligence provides personalized treatment - using multiple real time physiologic and subjective ...

DESCRIPTION (provided by applicant): One in nine women suffer from pelvic floor dysfunction, including urinary incontinence and vaginal wall or uterine prolapse (VUP). Stress urinary incontinence (SUI) affects 38% of women over the age of 65 years and over 13 million women in the United States. Pelvic muscle strength is commonly assessed in these patients. However, current measurement techniques a ...

Metabolism of arichidonic acid by 12-lipoxygenase results in the formation of 12(s)-hydroxy eicosatetraenoic acid, which exhibits profound biological activity and plays an important role in tumor cell survival, angiogenesis, and metastases. Prostate cancer is the most commonly diagnosed neoplasm and second leading cause of male death in the United States. Human prostate cancer cells express incre ...

DESCRIPTION (provided by applicant): Conventional methods to identify and test the antibiotic susceptibility of Mycobacterium tuberculosis are both slow and insensitive. Current nucleic acid amplification-based techniques present a partial solution by offering a more rapid result, but these methods require a relatively high degree of technical sophistication. Furthermore, assay sensitivity is oft ...

DESCRIPTION (Adapted from applicant's abstract): The application's long-term objective is to improve the treatment of acute ischemic stroke by using mechanical embolectomy for arterial recanalization. The specific aim of this project is to design and test various versions of the Clot Retriever Device (CRD), a helix shaped nitinol device made to ensnare and retrieve thrombo-emboli from cerebral art ...