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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention

    SBC: NANOMED PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Despite concerted efforts to improve therapy, five year survival rates for patients with advanced stage oral squamous cell carcinoma (SCC) remain discouragingly low. Clearly, early detection combined with strategies for local intervention, such as chemoprevention prior to SCC development, could dramatically improve clinical outcomes. The results of previously c ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. Fluorescence lifetime method for guided therapy of brain tumors

    SBC: MICROSURGEON, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose clinical evaluation and optimization studies of time-resolved fluorescence spectroscopy (TR-LIFS) technique for the intraoperative identification of tumor vs. normal brain during neurosurgical resection of brain tumors. A critical need currently for neurosurgeons operating on infiltrative glial neoplasms is the ability to distinguish between normal ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Family Empowerment: Adapting Successful Disclosure Strategies for HIV+ Parents

    SBC: SCIENCE2MARKET, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): One million adults in the US and 42 million families globally must decide if, to whom, when, and how to disclose their HIV+ serostatus. Often, disclosure of serostatus has a long-term negative impact on children and extended family members of HIV+ parents; this team has developed a coping-skills intervention that can positively impact the adjustment over 6 year ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Evolutionary Approaches for synthetic Library Design

    SBC: DNA Twopointo Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Directed evolution has been widely employed to enhance protein structural stability and activity, expand functionality and alter specificity. We propose a novel approach for generating libraries of variant genes that takes advantage of the evolutionary history of a gene family by generating a combinatorial library incorporating amino acid replacements inferred ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy

    SBC: VESTAN INC            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this grant is to develop fluorescence endoscopy instrumentation to facilitate the surgical management of breast cancer, with possible application to other types of cancer. The specific aims for this project are to develop a combination holographic notch filter adapter and switchable high-intensity LED light source adapter for currently availabl ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Embryonic stem cell high throughput screen accurately reports toxic stress

    SBC: REPRODUCTIVE STRESS MEASUREMENT MECHANISMS & MANAGEMENT CORP            Topic: NIEHS

    State of the art techniques in Developmental and Reproductive Technology use slowexpensive testing of pregnant female rodentsor of embryonic stem cellsESCsthat are cultured to lose stem cell qualities and differentiate into organ tissuesThis only produces toxicological outcomes similar to those in adult versions of these organsReproductive StressM has established high throughput screensHTSsthat te ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Discovery of novel CDK4/6-PI3K-BRD4 inhibitor SRX3177 for augmented anti-cancer activity

    SBC: SignalRx Pharmaceuticals Inc.            Topic: 102

    Three CDKinhibitors were recently approved to treat breast cancerBrCAin combination regimentsDespite significant clinical activitytreatment of BrCA patients with these combinations does not result in a durable responseHencethere is an unmet medical need to develop targeted therapeutic agents which will augment the activity of CDKinhibitors in BrCA and other CDKcyclin D Myc dependent malignanciesA ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Device for Acamprosate Transcutaneous Delivery to Reduce Alcohol Consumption.

    SBC: Technova Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Alcohol dependence is a chronic disorder with genetic, psychosocial, and environmental underpinnings. Alcohol's societal impact is widespread; it is estimated that there are 17.6 million individuals who abuse or depend on alcohol in the United States. (Grant et al, 2004). Alcohol dependence is considered the third leading preventable cause of death in the Unite ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Nur77/TR3 Peptide Mimetics for the Treatment of Cancer

    SBC: VIVO LABORATORY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apoptosis is well recognized as an important biological process that controls cancer development and progression and the efficacy of chemotherapeutic drugs depends largely on their ability to induce apoptosis. Modern biology has suggested that cancer drug discovery based on molecular differences between tumor and normal cells is a feasible approach. Bcl-2, a cr ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Point of Care Diagnostic Screening test for Kawasaki disease

    SBC: L2 DIAGNOSTICS LLC            Topic: NICHD

    ABSTRACT Kawasaki DiseaseKDis a febrile childhood vasculitis with potentially catastrophic clinical outcomesUntreatedone in five children develop coronary artery aneurysms causing significant morbidity and mortalityTypical KD presents as a febrile illness andgtdays in children andltyears oldThere are no diagnostic tests for KDit is diagnosed clinically based on a fever andgtdays with at leastofphy ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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