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Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and TherapeuticsSBC: SAB CAPRA, LLC Topic: NIAID
Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: PHOENIX PHARMALABS, INC. Topic: NIDA
Abstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Mitovation, Inc. Topic: 101
Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NEONC TECHNOLOGIES INC Topic: 102
Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: REPRODUCTIVE STRESS MEASUREMENT MECHANISMS & MANAGEMENT CORP Topic: NIEHS
State of the art techniques in Developmental and Reproductive Technology use slowexpensive testing of pregnant female rodentsor of embryonic stem cellsESCsthat are cultured to lose stem cell qualities and differentiate into organ tissuesThis only produces toxicological outcomes similar to those in adult versions of these organsReproductive StressM has established high throughput screensHTSsthat te ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical ProstatectomySBC: MICROCURES INC Topic: 300
Radical prostatectomyRPis a commonly used treatment option for localized prostate cancerUnfortunatelythe procedure carries a risk of post surgical complications including a high risk of erectile dysfunctionEDAccording to The Prostate Cancer Outcomes Studyvirtually all men experience ED after surgeryincluding a profound loss of nocturnal erectionsThe Prostate Cancer Outcomes Study further reveals t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline BurnSBC: MICROCURES INC Topic: NEI
The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Veristride, Inc. Topic: 600
Veristride IncProject Summary When surveyedof stroke survivors said the ability toget out and aboutis considered between important and essential for a better lifeHoweverthat desire falls short of reality for most stroke survivorsOftenwalking across a neighborhood street or from a car to a home is an insurmountable task with little opportunity for working on improvement in gaitOnce insurance covera ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ZMK Medical Technologies, Inc. Topic: 102
ABSTRACTProstate cancerPCais one of the most commonly occurring forms of canceraccounting forof all cancer in menMulti parametric magnetic resonance imagingmpMRIhas led to improved capabilities for detectinglocalizingand staging PCaCombined with image guided prostate biopsympMRI has helped to improve diagnosis of clinically significant PCawhich helps to reduce mortality as well as unnecessary biop ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
In vitro and in vivo evaluation of elephant p53 (EP53) protein nanoparticles for pediatric osteosarcomaSBC: Peel Therapeutics, Inc Topic: 102
PROJECT SUMMARY ABSTRACT PEEL TherapeuticsIncis a life sciences company created to impact the lives of people with cancerBased on the research efforts of DrJoshua Schiffman and DrAvi SchroederPEEL TherapeuticsPEELhas created liposomal nanoparticles that have been loaded with elephant pEPproteins as a new class of anti cancer protein therapeuticsElephants have an unexpectedly low rate of cancer giv ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health