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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Osteopontin targeted therapy for primary CNS lymphoma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Robust Predictor of Breast Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 103

    Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...

    STTR Phase I 2017 Department of Health and Human Services
  3. Developing Multi-targeting Antiviral Agents Against Herpes Simplex 1

    SBC: Quercus Molecular Design, LLC            Topic: NIAID

    Viruses from the human herpesvirus family are estimated to infectof the adult population worldwide and are responsible for lifelong debilitating and congenital infectionsSome members of this family are associated with human cancers and age related cognitive declineHerpes simplex virusHSVhas infected more thanbillion people under the age ofof the populationHSVcauses significant disease during acute ...

    STTR Phase I 2017 Department of Health and Human Services
  4. A single-cell device to capture and analyze rare T-cells from solid tumors.

    SBC: IsoPlexis            Topic: 102

    Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease

    SBC: IsoPlexis            Topic: NIBIB

    MyelofibrosisMFbelongs to a group of closely related chronic blood diseasesmyeloproliferative disordersMPDMost MF patients have no symptoms or present with nonspecific constitutional symptomsweight lossfatigueas such an early stage diagnosis of MF is challengingMF is clinically suspected when patients present with an enlarged spleen and or with anemiathrombocytopeniaor leukopenia leukocytosishowev ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics

    SBC: IsoPlexis            Topic: 100

    With this PhasesubmissionIsoPlexis proposes to deliver a single cell proteomic solution for ultra sensitive detection of unique correlative biomarkers in pre clinical mouse modelsin an automated system that can be used to accelerate the discovery of potential immune therapeuticsThe recent revolution in new basic science discovery is failing to translate into improved patient treatmentThe reduction ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. PEM based Vacuum Desalination System

    SBC: Xergy Inc            Topic: 09c

    The Company’s development is addressing one of the most basic human needs: access to potable water. Without adequate potable water, society succumbs to human suffering i.e. dehydration, disease and inevitably limited supply results in human conflict. There is therefore a need for an efficient, and cost effective method of producing quality potable water from low grade sources such as brackish or ...

    SBIR Phase II 2017 Department of Energy
  9. Inflatable Capsule Recovery Raft using OTS Pontoons and Other Components

    SBC: ASRC Federal System Solutions, LLC            Topic: H1002

    The objective of the proposed innovation is to research and study the feasibility of using pontoons (based on Off the Shelf (OTS) equipment) to make an inflatable raft that will support a water-landed space capsule. The advantages of this approach over traditional methods are: 1) Provides stable platform to open hatch for Flight Crew access/egress in less than 1 hour from the time the recovery ves ...

    SBIR Phase I 2017 National Aeronautics and Space Administration
  10. Impact-Resistant, Damage-Tolerant Composites with STF Energy Absorbing Layers

    SBC: STF Technologies LLC            Topic: H401

    We propose an innovative hybrid composite that combines the smart energy-absorbing shear thickening fluids (STF) with validated hard upper torso composite materials to create new STF composite structures with superior impact and damage resistance and self-healing functionality. The proposed innovation directly addresses the subtopic H04.01 need for thin, lightweight composite materials that can be ...

    SBIR Phase I 2017 National Aeronautics and Space Administration

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