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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Bifunctional Redox Agent for the Treatment of PPHN

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening neonatal condition wherein an elevation in pulmonary vascular resistance after birth diverts pulmonary blood flow via a right-to-left shunt,at the levels of the ductus arteriosus and foramen ovale, into the systemic circulation. Current therapy includes mechanical ventilation, oxygen, ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. 12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

    SBC: E-TROLZ, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monit ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Intramural drug infusion balloon for preventing vascular restenosis

    SBC: MEDI-SOLVE COATINGS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Recently, drug coated balloons (DCB) have emerged as a promising alternative for treating stenosed arterial vessels. The demonstrated efficacy of DCB is tempered by the risk of distal arterial embolism, which can resultfrom systemic drug exposure caused by premature dissolution or delamination of the drug coating into the blood stream during catheter insertion ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Development of HeartLander as an epicardial injection delivery system

    SBC: HEARTLANDER SURGICAL, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Numerous innovative therapies that must be delivered into the heart wall are now under development. These therapies typically require precise placement of a precise measure of an injectable substance and are intendedto be delivered by minimally invasive means to minimize patient trauma. Unfortunately, traditional approaches for delivering such therapies, suc ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. NEURON2GPU: Transformative Neural Simulation Using Desktop GPU Technology

    SBC: INFORMED SIMPLIFICATIONS, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Researchers are now able to perform computational physiology and pharmacology experiments on realistic model neurons with accurate geometries and full complements of membrane biophysics and biochemistry; however, the practical utility of such simulations are restricted because of the limitations of current commodity computer hardware. We will provide real time, ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Motivational Interviewing: An Experiential Online Training Tool

    SBC: C4 Innovations, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): The Center for Social Innovation (C4SI) proposes to develop and pilot test the Motivational Interviewing Simulator: An Experiential Online Training Tool. Motivational Interviewing (MI) is a well-established evidence- based practice that has been implemented across a wide range of disciplines including mental health and substance abuse treatment, primary care, H ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Web-Based Program to Improve Antidepressant Medication Adherence

    SBC: ISA ASSOCIATES INC            Topic: NIMH

    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older. Among mental health problems, majordepressive disorder is the leading cause of disability in the U.S. for people ages 15-44, affecting nearly 15 million adults each year. While res ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Novel serotonergic, pro-cognitive antipsychotic therapies

    SBC: Galenea Corporation            Topic: NIMH

    DESCRIPTION (provided by applicant): This application, Novel serotonergic, pro-cognitive antipsychotic therapies , is in response to PA-08-142: Pharmacologic Agents and Drugs for Mental Disorders (SBIR [R43/R44]). Schizophrenia is a devastating brain disorder that affects approximately 0.7% of the global population. The symptoms of schizophrenia can be grouped into three major categories: posit ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. In vitro tools for preclinical analysis of cognitive therapies for schizophrenia

    SBC: Galenea Corporation            Topic: NIMH

    DESCRIPTION (provided by applicant): Schizophrenia is a debilitating disease that afflicts 1% of the US population. Symptoms of schizophrenia are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, socialisolation) and cognitive (impaired attention, executive function, working memory). Existing antipsychotics, while effective at treating the posit ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Benzodiazepine Analogs as Novel Treatments for Catatonia

    SBC: Organix Incorporated            Topic: NIMH

    DESCRIPTION (provided by applicant): Catatonia is a widespread and serious syndrome characterized by mutism, stupor, refusal to eat or drink, posturing, and hypokinesis, and affects a broad range of psychiatric and other patients in the US and worldwide. Untreated or poorly managed catatonic patients suffer from a wide range of ailments including bed sores, deep venous thrombi, pulmonary emboli, u ...

    SBIR Phase I 2011 Department of Health and Human Services

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