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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. New Reagents for the Synthesis of Phosphorodithioate-Modified 2'-O-Methyl RNAs

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Functional RNA molecules such as aptamers, siRNAs, miRNAs, and related compounds have enormous potential as human therapeutics and as tools for elucidating gene regulation in vivo. To reach this potential, such molecules must be highly potent and highly nuclease resistant. Unmodified RNAs typically do not meet these requirements. A variety of chemical modificat ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Methods and Instrumentation for Hydrostatic Pressure-Enhanced Tissue Fixation

    SBC: PRESSURE BIOSCIENCES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Fixation of tissue samples with formalin and paraffin is an established approach for long-term storage of tissues for later histological analyses. These formalin-fixed paraffin-embedded tissues can also be used for DNA,RNA or protein extraction for retrospective molecular studies. Unfortunately, traditional preservation methods do not guarantee uniform fixation ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Bifunctional Modulation of Redox Imbalance for Treatment of Septic Shock

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Sepsis accounts for gt 500K hospitalizations in the USA yearly, of which half will progress to a fatal outcome. Because there are no approved pharmaceutical agents that profoundly improve outcome, the mainstay of care is supportive administration of fluids, oxygen, mechanical ventilation, and antibiotics. Sepsis is driven by widespread tissue injury mediated by ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Improving self delivering properties of RNAi compounds through medicinal chemistr

    SBC: RXI PHARMACEUTICALS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the ability to apply this technology to human disease has been impeded by the absence of efficient and non ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Development of Specific Gene Silencing Methods and Reagents

    SBC: BOSTON BIOMEDICAL, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): RNA interference (RNAi), a potent and selective gene silencing mechanism, has revolutionized the field of biological science. The ability of RNAi to specifically down-regulate the expression of any gene has had a profound impact on the study of gene function, and holds great promise for in vivo functional genomics. The current paradigm for inducing RNAi in mam ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Development of a novel assay for the analysis of newly synthesized RNA

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): While changes in mRNA decay rates account for approximately 50% of the regulation of gene expression in the cell, an assay to accurately and reliably measure mRNA half lives is currently not available. In particular, the deficiency of reliable commercial kits which enable the average biomedical research lab to effectively investigate mRNA decay rates is signifi ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Development of an Instrument to Determine Protein Stability at any Desired Temper

    SBC: AVIA BIOSYSTEMS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein therapeutics is the fastest growing segment in the biotechnology and pharmaceutical industry. Protein therapeutics includes monoclonal antibodies, recombinant proteins, chimeric proteins and other protein receptor constructs. It is expected to reach over 70 billion in sales by 2010. A major hurdle in the development of proteins as pharmaceutical drugs ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Monolithic Media and Technology for Bioprocessing

    SBC: BIOLINK PARTNERS            Topic: NIGMS

    DESCRIPTION (provided by applicant): The objective of this work is to develop new manufacturing technology for large-scale production of recombinant proteins. Purification technology for large biomolecules such as monoclonal antibodies is an important component of biological research and for the production of therapeutic proteins that are used in a growing number of cancer therapies and other appl ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Snapshot Image Mapping Spectrometer (IMS) for High Resolution Biological Imaging

    SBC: REBELLION PHOTONICS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Snapshot Image Mapping Spectrometer (IMS) for High Resolution Biological Imaging Indirect Imaging is proposing, through the SBIR funding mechanism, to develop an innovative imaging device that will allow economical snapshot hyperspectral imaging for real time microscopy and other biomedical applications, and is compatible with most research grade light microsco ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Improving Pediatric Developmental Screening and Communications: A CME

    SBC: New England Research Institutes, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): Developmental delays are common in early childhood, affecting at least 10 percent of children and are markers for later developmental conditions. It is well established that the tremendous adaptability of the brain in the first three years of life means that early treatment of delays leads to improved outcomes, whereas later intervention is less effective. In o ...

    SBIR Phase I 2011 Department of Health and Human Services

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