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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of Specific Gene Silencing Methods and Reagents

    SBC: BOSTON BIOMEDICAL, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): RNA interference (RNAi), a potent and selective gene silencing mechanism, has revolutionized the field of biological science. The ability of RNAi to specifically down-regulate the expression of any gene has had a profound impact on the study of gene function, and holds great promise for in vivo functional genomics. The current paradigm for inducing RNAi in mam ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Development of an Instrument to Determine Protein Stability at any Desired Temper

    SBC: AVIA BIOSYSTEMS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein therapeutics is the fastest growing segment in the biotechnology and pharmaceutical industry. Protein therapeutics includes monoclonal antibodies, recombinant proteins, chimeric proteins and other protein receptor constructs. It is expected to reach over 70 billion in sales by 2010. A major hurdle in the development of proteins as pharmaceutical drugs ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Monolithic Media and Technology for Bioprocessing

    SBC: BIOLINK PARTNERS            Topic: NIGMS

    DESCRIPTION (provided by applicant): The objective of this work is to develop new manufacturing technology for large-scale production of recombinant proteins. Purification technology for large biomolecules such as monoclonal antibodies is an important component of biological research and for the production of therapeutic proteins that are used in a growing number of cancer therapies and other appl ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Smaller Particle Fused-Core Silicas for Higher Performance Separations

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules suchas proteins, peptides, glycopeptides, and glycans. Many HPLC separations of biomedical interest, such as proteomic or glycomic profiling, require ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Improving Pediatric Developmental Screening and Communications: A CME

    SBC: New England Research Institutes, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): Developmental delays are common in early childhood, affecting at least 10 percent of children and are markers for later developmental conditions. It is well established that the tremendous adaptability of the brain in the first three years of life means that early treatment of delays leads to improved outcomes, whereas later intervention is less effective. In o ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Infant Breath

    SBC: AGILTRON, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall goal of this proposed research is to adopt an inexpensive IR camera and image analysis software for non-contact monitoring the breath of a premature infant. Sleep apnea in these patients can lead to significant health problems, even death. Existing sensors can give false signals. An all optical system that can detect CO2 in the baby's breath wi ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. VASCULAR SENSOR FOR WOMEN'S REPRODUCTIVE HEALTH RESEARCH

    SBC: CORPORA SYSTEMS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): It is estimated that around 45-60 million American women suffer from sexual disorders at some point in their lives. In comparison, about 30 million men are afflicted with comparable conditions. In both men and women, sexual disorders can be associated with a number of clinical conditions, including diabetes, heart disease, hypertension, multiple sclerosis, and ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Powered Walk/Run Prosthetic Ankle, PWR Ankle

    SBC: Springactive, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): This proposal will utilize innovative, technologies to allow below the knee amputees to walk and run using a single powered prosthetic device. Current users of passive prosthetic devices typically expend more energy; have reduced ankle motion and power; and increased gait asymmetry resulting in joint and back pain. Augmenting ankle power with a robotic tend ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Development and Commercial Optimization of Circular DNA Conversion for Opti-pore

    SBC: NOBLEGEN BIOSCIENCES, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): NobleGen Biosciences was founded based upon the groundbreaking work of Dr. Amit Meller's lab at Boston University in which they demonstrated the proof of concept for a unique, nanopore based method for DNA sequencing bynanopore induced photon emission (SNIPE), which utilizes optical detection rather than the more ubiquitous electrical detection. The proces ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Steerable Oxygen Sensing Catheter for Cardiac Resynchronization Therapy (CRT) Pro

    SBC: OXUS MEDICAL, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): A system is constructed for navigation feedback during an interventional cardiology procedure for Cardiac Resynchronization Therapy (CRT) by seeking out the location with low oxygen saturation, which coincidentally is the place for the implantation of leads to pace the heart. Heart failure affects 22 million people worldwide. In many of these patients, an abnor ...

    SBIR Phase I 2011 Department of Health and Human Services

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