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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of Specific Gene Silencing Methods and Reagents

    SBC: BOSTON BIOMEDICAL, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): RNA interference (RNAi), a potent and selective gene silencing mechanism, has revolutionized the field of biological science. The ability of RNAi to specifically down-regulate the expression of any gene has had a profound impact on the study of gene function, and holds great promise for in vivo functional genomics. The current paradigm for inducing RNAi in mam ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. A Novel System for Mass Production of iPS Cells

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Primorigen Biosciences LLC SBIR Project Abstract Primorigen will use SBIR funds to develop and validate a microcarrier-based cell culture system for selection, scale-up and feeder-free mass production of iPS cells, based on Primorigen's proprietary pluripotent stem cell attachment factor (StemCadhere ) for direct physical selection and propagation of iPSC. ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Development of an Instrument to Determine Protein Stability at any Desired Temper

    SBC: AVIA BIOSYSTEMS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein therapeutics is the fastest growing segment in the biotechnology and pharmaceutical industry. Protein therapeutics includes monoclonal antibodies, recombinant proteins, chimeric proteins and other protein receptor constructs. It is expected to reach over 70 billion in sales by 2010. A major hurdle in the development of proteins as pharmaceutical drugs ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Monolithic Media and Technology for Bioprocessing

    SBC: BIOLINK PARTNERS            Topic: NIGMS

    DESCRIPTION (provided by applicant): The objective of this work is to develop new manufacturing technology for large-scale production of recombinant proteins. Purification technology for large biomolecules such as monoclonal antibodies is an important component of biological research and for the production of therapeutic proteins that are used in a growing number of cancer therapies and other appl ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. High Throughput Assay for Detecting Protein Modifications in Cell Lysates

    SBC: Bellbrook Labs, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Post translational modifications (PTMs) such as phosphorylation, glycosylation and methylation play a central and ubiquitous role in cellular signal transduction, and the enzymes that catalyze these reactions such as kinases and methyltransferases are the targets of intense drug discovery efforts for virtually every therapeutic area, with the most intense focus ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Improving Pediatric Developmental Screening and Communications: A CME

    SBC: New England Research Institutes, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): Developmental delays are common in early childhood, affecting at least 10 percent of children and are markers for later developmental conditions. It is well established that the tremendous adaptability of the brain in the first three years of life means that early treatment of delays leads to improved outcomes, whereas later intervention is less effective. In o ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Infant Breath

    SBC: AGILTRON, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall goal of this proposed research is to adopt an inexpensive IR camera and image analysis software for non-contact monitoring the breath of a premature infant. Sleep apnea in these patients can lead to significant health problems, even death. Existing sensors can give false signals. An all optical system that can detect CO2 in the baby's breath wi ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. VASCULAR SENSOR FOR WOMEN'S REPRODUCTIVE HEALTH RESEARCH

    SBC: CORPORA SYSTEMS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): It is estimated that around 45-60 million American women suffer from sexual disorders at some point in their lives. In comparison, about 30 million men are afflicted with comparable conditions. In both men and women, sexual disorders can be associated with a number of clinical conditions, including diabetes, heart disease, hypertension, multiple sclerosis, and ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. An innovative tool for assessment of gait dysfunction in the clinical setting

    SBC: METRIA INNOVATION, INCORPORATED            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall goal of this SBIR Phase I proposal is to establish the measurement reliability and the clinical feasibility of the RGR-GAIT instrumented gait analysis system. Gait dysfunction can dramatically affect a person's ability to perform activities of daily living, and assessment of gait is a critical component of physical therapy practice. Currently, ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Functional Selection of High Performance Enzymes

    SBC: LUCIGEN CORPORATION            Topic: NHGRI

    DESCRIPTION (provided by applicant): Microfluidic systems are emerging as critically important tools for high throughput cell based analysis for applications including genotyping, sequencing, gene expression analysis, nucleic acid amplification, and diagnostics. Lab-on-a-chip devices that are conventionally designed to perform microchemical reactions in a continuous flow require external component ...

    SBIR Phase I 2011 Department of Health and Human Services

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