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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 51 - 60 of 23867 results
  1. Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells

    SBC: Giner, Inc.            Topic: NIDDK

    PROJECT SUMMARY Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells The overall goal of the SBIR project is to develop an advancedminiaturized implantable electrochemical oxygen generator that supplies oxygen at well regulated dose and concentration to cells within an immunoisolation deviceso as to ensure their viability and function at high density and minimize o ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Real-time Avoidance of Weather Hazards In Dynamic Environments (RAWHIDE)

    SBC: Charles River Analytics, Inc.            Topic: N182099

    Unmanned systems play a critical military role, and require the ability to fly through areas of operations on a near-all-weather 24/7 basis so potential weather-related incidents can be avoided (OSD, 2013). To increase UAS flight safety and avoid weather phenomena (e.g., clouds, haze, ash), we propose a system for Real-time Avoidance of Weather Hazards In Dynamic Environments (RAWHIDE) to dynamica ...

    SBIR Phase I 2019 Department of DefenseNavy
  3. Multicore Fiber Optic Package Optical Subassembly for Wideband Digital and Analog Photonic Links

    SBC: PHASE SENSITIVE INNOVATIONS            Topic: N182101

    In this SBIR effort we will develop a balanced detection analog photonic link consisting of a DFB laser, a dual-output high-speed, low-Vp mach-zehnder modulator (MZM) and a high-power, high-linearity balanced photodetector (BPD) using a dual-core, single mode, multicore fiber (MCF) that is supplied by our subcontractor, OFS. We will design, fabricate and characterize (phase I) the MZM and the BPD, ...

    SBIR Phase I 2018 Department of DefenseNavy
  4. Photonic Integrated Circuit Reliability

    SBC: PHASE SENSITIVE INNOVATIONS            Topic: N182108

    Photonic integration, and specifically silicon photonics, has emerged as one of the leading solutions for maintaining or improving the performance of optical systems while addressing the requirements related to size, weight, and power (SWaP). Photonic integrated circuits (PICs), which integrate multiple photonic elements onto a single chip, are specifically suited to providing the complexity and f ...

    SBIR Phase I 2018 Department of DefenseNavy
  5. Clinical Translation of a Novel Diagnostic Agent to Predict Immunotherapy Response in Solid Tumors

    SBC: CytoSite BioPharma Inc.            Topic: 102

    Over the past three years an entirely new cancer treatment paradigm has emerged following the FDA approval ofdifferent checkpoint inhibitors for a number of indications includingmetastatic melanoma and non small cell lung cancerThese new agents work by effectively releasing the brakes on the immune system that normally limit the body s natural responses to tumor cells and have generated long term ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. A Computer Aided Diagnosis(CAD) Algorithm for Identification of Dysplasia in Patients with Barrett Esophagus

    SBC: Ninepoint Medical, Inc.            Topic: 102

    ABSTRACT The goal of this project is to develop a based computer aided diagnosisCADalgorithm for identification of regions at risk for developing esophageal adenocarcinomaEACin optical coherence tomographyOCTscans of the esophagusEAC is one of the deadliest cancers with ayear survival rate of less thanyet the standard of care for detecting precursors to EAC is widely recognized to be inadequateJus ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Bacterial delivery of phosphatase antagonists to metastatic breast cancer

    SBC: ERNEST PHARMACEUTICALS LLC            Topic: NCI

    Summary At this timethere is no cure for metastatic breast cancerThe prognosis for these patients is poorWith current standard of care treatmentsthe median survival time is three yearsWe propose to develop a novel bacterial drug delivery therapy into an effective and low toxicity therapeutic for breast cancer metastasesthat targets protein phosphatasePPAberrant phosphorylation in cell signaling is ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Robust Predictor of Colon Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 102

    Summary At leastpeople in the United States are at high risk for Lynch syndromebased on inheritance of a genetic mutation in the mismatch repairMMRor double strand breakDSBrepair pathwayMore than half of them are unaware of their riskbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in this pathwaybut in a large number of cases no mutati ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Use of Raman spectroscopy to measure mitochondrial redox state as a marker of tissue injury in donor livers

    SBC: Pendar Technologies, LLC            Topic: 300

    Abstract With more than five times the number of patients on the wait list than will receive a donor organ in the United Statesthe field of transplantation is facing a serious donor shortage crisisThe lack of available biomarkers for assessment of organ injury due to ischemia injury results in unnecessary waste of high quality organsWe aim to establish mitochondrial redox statemeasured on the tiss ...

    SBIR Phase I 2018 Department of Health and Human Services

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