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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. GENETIC ENGINEERING OF AN IMPROVED FACTOR VIII PRODUCT

    SBC: Genetics Institute Inc.            Topic: N/A

    FACTOR VIII IS THE PLASMA PROTEIN THAT IS FUNCTIONALLY DEFICIENT IN HEMOPHILIA A PATIENTS, RESULTING IN THE CLINICAL BLEEDING DISORDER. PATIENTS WITH THIS DISEASE REQUIRE FREQUENT INFUSIONS OF FACTOR VIII IN ORDER TO MAIN- TAIN HEMOSTASIS, PARTICULARLY DURING SURGERY OR FOLLOWING PHYSICAL TRAUMA. PRESENTLY, THE COMMERCIAL FACTOR VIII PRODUCT IS PURIFIED FROM POOLED BLOOD PLASMA OBTAINED FROM HUMAN ...

    SBIR Phase II 1988 Department of Health and Human Services
  2. PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES IN TRANSGENIC MICE

    SBC: Genetics Institute Inc.            Topic: N/A

    MONOCLONAL ANTIBODIES HAVE IMMENSE POTENTIAL FOR USE AS PROPHYLACTIC, DIAGNOSTIC, AND THERAPEUTIC AGENTS IN THE TREATMENT OF VARIOUS TYPES OF HUMAN AILMENTS. FOR MANY USESIT IS DESIRABLE TO USE HUMAN MONOCLONAL ANTIBODIES AS OPPOSED TO MURINE MONOCLONAL ANTIBODIES. ALTHOUGH MANY APPROACHES HAVE BEEN ATTEMPTED TO PRODUCE HUMAN MONOCLONAL ANTIBODIES, SERIOUS LIMITATIONS HAVE BEEN ENCOUNTERED. THE AI ...

    SBIR Phase II 1988 Department of Health and Human Services
  3. PURIFICATION OF HIGH MANNOSE OLIGOSACCHARIDES

    SBC: Genzyme Corp.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  4. ALCOHOL MEASUREMENTS FOR TREATMENT COMPLIANCE

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  5. ELECTROCHEMICAL REACTOR TO DISINFECT REUSED DIALYZERS

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  6. ELECTROCHEMICAL GENERATOR FOR IN-HOME OXYGEN THERAPY

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  7. OBJECTIVE ANALYSIS OF SPERM MOTION AND MEMBRANE FUNCTION

    SBC: HAMILTON-THORN RESEARCH, INC.            Topic: N/A

    MULTIPARAMETER ANALYSIS OF SPERMATOZOAL FUNCTION IS NECESSARY FOR ACCURATE ASSESSMENT OF VIABILITY. BY ADAPTINGAN OBJECTIVE, AUTOMATED SPERM MOTION ANALYZER (HTM-2000) TO MEASURE FLUORESCENCE INTENSITY OF VARIOUS SUPRAVITAL STAINS AND MEMBRANE PROBES, AN ASSAY WILL BE DEVELOPED WHICH SIMULTANEOUSLY EVALUATES MOTILITY PARAMETERS (MOTILE FRACTION, VELOCITY, LINEARITY, ETC.) AND MEMBRANE INTEGRITY ON ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. HEALTHPRIZE 500 MOTIVATION KIT FOR COST EFFECTIVE QUITTING

    SBC: Health Innovations Inc            Topic: N/A

    RECENT RESEARCH SUGGESTS THE NEED TO DEVELOP A VIABLE ALTERNATIVE TO CURRENT SMOKING CESSATION PROGRAMS. THE PURPOSE OF THIS PROJECT IS THUS THREEFOLD: (1) TO DEVELOP A HEALTHPRIZE 500 MOTIVATION ENHANCEMENT KIT AS A COST EFFECTIVE, MINIMAL INTERVENTION ALTERNATIVE APPEALING TO A BROAD SPECTRUM OF SMOKERS AND ACCELERATING THE SMOKING CESSATION PROCESS; (2) TO TARGET DEVELOPMENT ESPECIALLY FOR THE ...

    SBIR Phase I 1988 Department of Health and Human Services
  9. RAPID PROCESSING OF BIOACTIVE PEPTIDES AND PROTEINS

    SBC: Helix International Corp            Topic: N/A

    A RAPID HIGH RECOVERY DIAFILTRATION PROCESS FOR THE SEPARATION AND PURIFICATION OF BIOLOGICALLY ACTIVE PROTEINS AND PEPTIDES WILL BE DEVELOPED AND DEMONSTRATED. THE MILD PROCESS CONDITIONS AND SIZE SELECTIVITY OF MEMBRANE FILTRATION WILL BE USED TO RECOVER BIOLOGICALLY PRODUCED FUSION PROTEINS OF 15,000 TO 20,000 MOLECULAR WEIGHT. THE FUSION PROTEIN WILL BE CONSTRUCTED TO CONTAIN THE DESIRED BIOLO ...

    SBIR Phase I 1988 Department of Health and Human Services
  10. IN VITRO CULTURE OF PREIMPLANTATION EMBRYOS

    SBC: Helix International Corp            Topic: N/A

    THE OBJECTIVE OF THIS STUDY IS TO DEVELOP AN IN VITRO CULTURE SYSTEM TO SUPPORT NORMAL DEVELOPMENT OF EARLY STAGE EMBRYOS TO BLASTOCYST STAGES. A SERIES OF FOUR EXPERIMENTS ARE PROPOSED IN WHICH FOUR TREATMENTS; 1) BOVINE TROPHOBLASTIC VESICLES, 2) FETAL BOVINE UTERINE CELLS, 3) OVIDUCTAL EPITHELIAL CELLS AND 4) SHELL-FREE CHICK EMBRYOS ARE USED AS FEEDER CELLS TO CO-CULTURE WITH EITHER MOUSE OR G ...

    SBIR Phase I 1988 Department of Health and Human Services

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