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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IMPROVED ACCURACY IN MANUAL BLOOD PRESSURE MEASUREMENTS

    SBC: Dynamedics Inc            Topic: N/A

    EFFORTS TO REDUCE MEASUREMENT VARIATION AND OBSERVER ERROR IN BLOOD PRESSURE MEASUREMENTS HAVE MET WITH SOME SUCCESS INRESEARCH AND INSTITUTIONAL ENVIRONMENTS. HOWEVER, THESE EFFORTS, WHICH INCLUDE THE RANDOM-ZERO SPHYGMOMANOMETER, THEZERO MUDDLER, AND AUTOMATED SPHYGMOMANOMETERS, HAVE GENERALLY NOT BEEN SUITABLE IN PROFESSIONAL AND OFFICE-BASEDCLINICAL APPLICATIONS WHERE MOST BLOOD PRESSURE MEASU ...

    SBIR Phase I 1988 Department of Health and Human Services
  2. DEVELOPMENT OF A THIN CERAMIC COATING FOR IMPLANTED DEVICE PROTECTION

    SBC: ECO ENERGY CONVERSION            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  3. DEVELOPMENT OF A NEW DOSAGE FORM FOR LONG-TERM STUDIES OF ^9-THC

    SBC: ElSohly Laboratories, Incorporated            Topic: N/A

    STUDIES IN THIS PROPOSAL WILL BE AIMED AT THE PREPARATION OFA SUPPOSITORY FORMULATION OF A PRO-DRUG OF DELTA-9-TETRA- HYDROCANNABINOL (^9-THC) AND STUDY THE BIOAVAILABILITY OF THC FROM THIS FORMULATION AS COMPARED TO I.V. ADMINISTRATIONOF BOTH THC AND ITS PRODRUG. BIOAVAILABILITY STUDIES WILL BE CONDUCTED IN MONKEYS, AND BLOOD SAMPLES WILL BE COLLECTEDAT 0, 15, 30, 60, 90, 120, 180, 240, AND 480 M ...

    SBIR Phase II 1988 Department of Health and Human Services
  4. GENETIC ENGINEERING OF AN IMPROVED FACTOR VIII PRODUCT

    SBC: Genetics Institute Inc.            Topic: N/A

    FACTOR VIII IS THE PLASMA PROTEIN THAT IS FUNCTIONALLY DEFICIENT IN HEMOPHILIA A PATIENTS, RESULTING IN THE CLINICAL BLEEDING DISORDER. PATIENTS WITH THIS DISEASE REQUIRE FREQUENT INFUSIONS OF FACTOR VIII IN ORDER TO MAIN- TAIN HEMOSTASIS, PARTICULARLY DURING SURGERY OR FOLLOWING PHYSICAL TRAUMA. PRESENTLY, THE COMMERCIAL FACTOR VIII PRODUCT IS PURIFIED FROM POOLED BLOOD PLASMA OBTAINED FROM HUMAN ...

    SBIR Phase II 1988 Department of Health and Human Services
  5. PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES IN TRANSGENIC MICE

    SBC: Genetics Institute Inc.            Topic: N/A

    MONOCLONAL ANTIBODIES HAVE IMMENSE POTENTIAL FOR USE AS PROPHYLACTIC, DIAGNOSTIC, AND THERAPEUTIC AGENTS IN THE TREATMENT OF VARIOUS TYPES OF HUMAN AILMENTS. FOR MANY USESIT IS DESIRABLE TO USE HUMAN MONOCLONAL ANTIBODIES AS OPPOSED TO MURINE MONOCLONAL ANTIBODIES. ALTHOUGH MANY APPROACHES HAVE BEEN ATTEMPTED TO PRODUCE HUMAN MONOCLONAL ANTIBODIES, SERIOUS LIMITATIONS HAVE BEEN ENCOUNTERED. THE AI ...

    SBIR Phase II 1988 Department of Health and Human Services
  6. PURIFICATION OF HIGH MANNOSE OLIGOSACCHARIDES

    SBC: Genzyme Corp.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  7. ALCOHOL MEASUREMENTS FOR TREATMENT COMPLIANCE

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  8. ELECTROCHEMICAL REACTOR TO DISINFECT REUSED DIALYZERS

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  9. ELECTROCHEMICAL GENERATOR FOR IN-HOME OXYGEN THERAPY

    SBC: Giner, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  10. OBJECTIVE ANALYSIS OF SPERM MOTION AND MEMBRANE FUNCTION

    SBC: HAMILTON-THORN RESEARCH, INC.            Topic: N/A

    MULTIPARAMETER ANALYSIS OF SPERMATOZOAL FUNCTION IS NECESSARY FOR ACCURATE ASSESSMENT OF VIABILITY. BY ADAPTINGAN OBJECTIVE, AUTOMATED SPERM MOTION ANALYZER (HTM-2000) TO MEASURE FLUORESCENCE INTENSITY OF VARIOUS SUPRAVITAL STAINS AND MEMBRANE PROBES, AN ASSAY WILL BE DEVELOPED WHICH SIMULTANEOUSLY EVALUATES MOTILITY PARAMETERS (MOTILE FRACTION, VELOCITY, LINEARITY, ETC.) AND MEMBRANE INTEGRITY ON ...

    SBIR Phase I 1988 Department of Health and Human Services

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