Award Data

DESCRIPTION (provided by applicant): Abstract The continued development of a rapid diagnostic method for testing the antibiotic susceptibility of urinary tract infections in near real-time is proposed. Currently, all methods for determining antibiotic susceptibility rely exclusively on detecting changes in the bacterial population caused by cell division after exposure to an antim ...

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) internal dia meter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. Currently, there is ...

THE USE OF ANTIBIOTIC THERAPY FOR INFECTION MANAGEMENT HAS INCREASED DRAMATICALLY IN THE AREA OF PERIODONTAL DISEASE AS AN ADJUNCT TO SCALING AND SURGERY TREATMENT. WITH THE EMERGENCE OF ANTIBIOTIC USE IN PERIODONTAL DISEASE CARE, ALMOST NO WORK HAS BEEN DONE IN ASSESSING THE DEVELOPMENT OF ANTIBIOTIC RESISTANCE IN DENTAL PLAQUE FLORA. BY DEVELOPING A DNA PROBE-BASED ASSAY FOR THE DETECTION OF ANT ...

THE ROLE OF EIKENELLA CORRODENS, FUSOBACTERIUM NUCLEATUM, AND WOLINELLA RECTA AS PATHOGENS ASSOCIATED IN DESTRUCTIVE PERIODONTAL DISEASE HAS BEEN DESCRIBED IN A NUMBER OF STUDIES USING CULTURE BASED ASSAY SYSTEMS. THE STANDARD CULTURE METHODS ARE INADEQUATE FOR THE ROUTINE DIAGNOSIS OF THESE PATHOGENS. BY DEVELOPING DNA PROBE-BASED ASSAYS FOR THE DETECTION OF THESE PATHOGENS, IT WOULD BE PRACTICAL ...

THE OVERALL OBJECTIVE OF THE PROJECT IS TO DEVELOP A TRANSDERMAL DOSAGE FORM OF THE H(1)-BLOCKER CARBINOXAMINE FOR 24-HOUR CONTROL OF ALLERGIC RHINITIS. IN PHASE I THE FEASIBILITY OF SUCH DOSAGE WILL BE TESTED. IN VITRO TRANSDERMAL PENETRATION EXPERIMENTS WITH NUDE MOUSE SKINS, AS WELL AS IN VIVO TESTS ON SHAVED RABBIT SKINS WILL BE USEDTO DETERMINE PERCUTANEOUS FLUX VALUES. FORMULATIONS OPTIMIZED ...

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DESCRIPTION (provided by applicant): Deubiquitinating enzymes play critical regulatory roles in the ubiquitin-proteasome pathway (UPP). Despite their relevance to human disease and interest by pharma as targets for therapeutic development, this diverse cla ss of enzymes is understudied and detailed biochemical data is lacking. Highly purified DUB enzymes and appropriate substrates for sensitive an ...

DESCRIPTION (provided by applicant): The recent discovery of RNAi has created the opportunity to develop an entirely new class of drugs against a variety of human diseases that work by silencing disease causing genes. The development of RNAi-based drugs, h owever, has been hampered by difficulties in delivery and manufacturing, as well as the activation of host interferon-like responses. Of these, ...

THE LONG RANGE OBJECTIVE OF THIS RESEARCH IS TO REDUCE THE TOXICITY AND CARCINOGENICITY OF ASBESTOS BY DESFERROXAMINE TREATMENT, WHICH NEUTRALIZES THE CATALYTIC ACTIVITY OF THE ASBESTOS-CONTAINED IRON. IN PHASE I OF THIS PROJECT THE POSSIBILITY THAT DESFERROXAMINE TREATMENT CAN REDUCE ASBESTOS-CAUSED SQUAMOUS METAPLASIA IN TRACHEAL ORGAN CULTURES WILL BE STUDIED. SQUAMOUS METAPLASIA IS THOUGHT TOP ...