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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): We are developing a novel immunomodulatory approach to arrest pancreatic islet injury and restore specific immune tolerance in new-onset Type 1 diabetes mellitus (T1D). Damage of pancreatic islets in T1D may result fromexcess pathogenic Th1/Th17 cells and deficient tolerance-inducing antigen (Ag)-specific Treg (FOXp3+CD25+) and Tr1 CD4+ cells (FOXp3-CD25- IL-10 ...

    SBIR Phase I 2013 Department of Health and Human Services
  2. Accurate Multi-Target MS Food Analysis

    SBC: HEPROTECH, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Drug-induced hepatotoxicity is the most common cause of acute liver injury, a potentially fatal condition for which current therapies are limited o supportive care and liver transplantation. It is also the most common reason that potentially life-saving drugs are abandoned during development and never reach patients. Heprotech Inc. was formed to develop liver-s ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): We are developing a novel small molecule cytoprotective drug (R-100) for the prevention of contrast- induced nephropathy (CIN) following IV radiocontrast media (CM) injection. R-100 is a novel cell- permeable redox-active agent formed from the covalent fusion of 2 chemical moieties: 1) an organic nitrovasodilator that donates nitric oxide, and 2) a pyrrolidine ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. Early diagnosis of acute kidney injury by aptasensors

    SBC: Aptalogic, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Acute kidney injury (AKI) affects more than 10 million people worldwide each year with reported mortalities from 15 to 60% in different patient populations. However, methods are lacking to support the early diagnosis ofAKI that could lead to early intervention, improved therapy, better prognosis, and lower medical costs. For these reasons, the development of ea ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Radioactive Stents for Brachytherapy of Esophageal Cancers

    SBC: ENERGESIS PHARMACEUTICALS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Obesity has reached epidemic proportions in the U.S. and plays a major role in the development of type 2 diabetes, dyslipidemia, and cardiovascular disease. There remains a very significant need for better non- surgicaltreatments. While most weight loss agents rely on suppressing appetite to reduce caloric intake, strategies that can safely enhance metabolic ra ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Sorted libraries of error-free long oligonucleotides

    SBC: BIOPHYSICS ASSAY LABORATORY, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Iron deficiency is frequently encountered in chronic kidney disease (CKD) patients and many other populations. Current oral iron formulations are poorly tolerated. Injectable iron preparations are difficult to administer, costly and have serious adverse reactions. Therefore, a highly absorbable, well tolerated oral iron supplement for the treatment of anemia a ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Long-Term Non-Enzymatic Glucose Sensors for an Artificial Pancreas

    SBC: Giner, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The overall goal of this proposed SBIR project is to develop a miniaturized implantable oxygen generator that will continuously supply oxygen to cells within an immunoisolation cell implant device. This will maintain cellular viability and function at high cell densities thus minimizing overall implant size. The oxygen generator will be powered by a remotely re ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. Advanced Nitric Oxide Release Bactericidal Urinary Catheters

    SBC: PHOTO DIAGNOSTIC SYSTEMS, INC.            Topic: NIBIB

    DESCRIPTION (provided by applicant): X-ray computed tomography (CT), which is widely used clinically, does not make full use of the spectral dependence of X-ray attenuation in tissues and contrast agents, and for that reason it delivers sub-optimal imagesat greater than necessary dose to the patient. CT alone contributes almost half the total radiation exposure for medical use in the US, and one q ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Genetically-delivered Bevacizumab for Treatment of Wet Age-Related Macular Degene

    SBC: REGENX BIOSCIENCES, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly intravitreal injections of the monoclonal bevacizumab in treating wet AMD that is accompanied by a high cost ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. A Novel Ultra-Wideband Gyrotron for DNP-NMR Research

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION: We propose to develop a tunable resonator/cavity for a 25 W, 395 GHz gyrotron with an ultra-wideband tuning of more than 6 GHz (1.5%) with near-constant power across the band. The gyrotron will be used for Dynamic Nuclear Polarization (DNP) enhanced solid-state and solution-state NMR spectroscopy. With DNP, the inherently small signal intensities in an NMR experiment can be enhanced b ...

    SBIR Phase I 2013 Department of Health and Human Services

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