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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Preclinical development of an intravaginal ring for the sustained release of Pritelivir for the treatment and prophylaxis of Genital Herpes in women

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: NIAID

    SUMMARY The broadlong term goal of this project is to develop a pritelivir intravaginal ringIVRfor the treatment and pre exposure prophylaxis of genital herpesa common problem that affects more thanmillion AmericansRecurrences are common and may be painfulInfection is life longPritelivir is a promisinghelicase inhibitor that proved superior to existing therapies in Phaseclinical trialsbut whose cl ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Development of a Human Liver Microphysiological System For Alcoholic Liver Disease

    SBC: Emulate, Inc.            Topic: 500

    PROJECT SUMMARYAlcoholic liver diseaseALDincludes a broad range of progressive disease stagesfatty liveralcoholic steatohepatitisASHliver fibrosisliver cirrhosisand hepatocellular carcinomaIn spite of being one of the major causes of morbidity and mortality in the worldthere are currently no effective strategies that can preventtreat or monitor the progress of ALD owing primarily to lack of human ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Cerberus therapy for metastatic disease

    SBC: Talapo Therapeutics            Topic: 102

    Metastasis is the most common cause of cancer related mortalityyet there are currently no therapeutic options that can be used to stop the spread of malignant cellsRecentlytwo members of the Transforming Growth Factorfamilythe secreted ligands Nodal and Bone Morphogenetic ProteinBMPhave been linked with increased metastasis in breast and other cancersThese cytokines activate stem cell programs in ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Multiplexed single-cell contractility assay to develop therapeutics for asthma and hypertension

    SBC: Forcyte Biotechnologies, Inc.            Topic: 100

    SUMMARYABSTRACT Asthmatic bronchoconstriction and hypertensive vasoconstriction are extremely common disease states in which excessive contractile cellular forces directly contribute to the pathophysiologyExisting treatments for these diseaseswhich affectmillion andmillion Americansrespectivelyhave severe side effectsbecome desensitized over prolonged useor lack efficacy altogetherIn particularLAB ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Synthetic biology E. coli strain development for expression of functional human GPCRs with roles in human disease

    SBC: PRIMORDIAL GENETICS Inc.            Topic: 400

    Project Summary Abstract G protein coupled receptorsGPCRsmediate most of our bodyandapos s physiological responses to hormonesneurotransmitters and environmental stimulantsThey are trans membrane proteins that are expressed in every type of cell in the body where their function is to detect molecules outside the cell and transmit signals across the membrane to activate cellular responsesThese prot ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Creating Live Interactions to Mitigate Barriers (CLIMB): A Mobile Intervention to Improve Social Functioning in People With Schizophrenia

    SBC: Posit Science Corporation            Topic: 104

    PROJECT SUMMARY ABSTRACT The goal of the current Phase I project is to developto clinical trial readinessand evaluate feasibility of a mobile ecological momentary intervention designed to improve social functioning in individuals with schizophreniaWhile effective treatments such as group based social skills training and computerized social cognition training are known to induce positive effects on ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Form factor determination for the Talon microIPG system to treat Chronic Migraine

    SBC: NeoGenesis Technologies LLC            Topic: NINDS

    Project Summary Worldwidetens of millions are afflicted with chronic migraineCMa highly debilitating neurological disorderWhile abortive and preventative therapies existthere are still nearlymillion peopleM in the US alonewho do not respond adequately to these therapies and suffer from Intractable Chronic MigraineICMThose patients are highly disabled by their disease and are faced with a significa ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Prehospital and Emergency Room Stroke Diagnosis Using Quantitative Cerebral Hemodynamics

    SBC: Neural Analytics, Inc.            Topic: NINDS

    Large vessel acute ischemic strokeAISis the leading cause of disability and fourth leading cause of death with approximatelyper year in the United States aloneAlthough treatments including interventionalstentrieverand pharmaceuticaltPAexist for large vessel occlusionLVOthere is not a rapid prehospital tool for diagnoses which guides the use of the correct therapyBecause the time to treatment for s ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Pan-HIV Incidence Assay Development

    SBC: ImmPORT Therapeutics Inc dba Antigen Discovery Inc            Topic: NIAID

    PanHIV Incidence Assay DevelopmentAbstractHIVcontinues to cause the largest number of yearly deaths from a single infectious agent in the world todayDespiteconsiderableadvancesintreatmentofHIVinfectionandAIDSwhichitcausesthereisanurgentneed for better methods of prevention and treatment of HIVinfection and AIDSAs part of this effortthe WorldHealth OrganizationWHOand the Joint United Nations Progra ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. HeartMapp: A Closed-Loop Assessment and Treatment Mobile Application for Heart Failure

    SBC: Posit Science Corporation            Topic: 600

    PROJECT SUMMARY The goal of the current Phase I project is to developto clinical trial readinessand evaluate the feasibility and initial efficacy of a mobile applicationHeartMappdesigned to monitor and treat physical and cognitive symptoms related to heart failureHFin older adultsHeart failureHFis a leading cause of death in the US with costs estimated at $billion per annumfueled by the high rates ...

    SBIR Phase I 2018 Department of Health and Human Services

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