Award Data

SUMMARY Dysregulation of epigenetic mechanisms is known to play important roles in the development and progression several disease states including cancerautoimmuneneurological and inflammatory disordersIn cancer alonehigh frequency mutations in sixty epigenetic regulatory proteins have been identifiedLike genome sequencingepigenetic information can be elucidated across the entire genome and profi ...

Project SummaryPeripheral arterial diseasePADis a highly prevalent condition that is growing rapidly due to shifting demographicsaffectingM people worldwide andM in the USAwith an annual growth rate ofApproximately one third of PAD patients experience lower extremity pain that limits activityand one third of these patients suffer from critical limb ischemiaCLIwhich lacks any effective treatment op ...

There exists an under-utilized portion of the electromagnetic spectrum, located between the microwave and infrared wavelengths, in the sub-millimeter band.This region, known as terahertz radiation, has historically been problematic to access.There have been numerous demonstrations of THz electronics using LTS Josephson junctions that provide precise frequency control and on-chip detection via the ...

Abstract The project concerns optical single molecule sequencing on a highly packed array of molecules in which individual molecules are not resolvable by standard diffraction limited imagingThe sequence of molecules is obtained by super resolving signal from individual molecules during the course of template directed DNA synthesisThe project willsynthesize and test the basic building blocks of th ...

SummaryAbstractThis Small Business Innovation ResearchSBIRPhase I project proposes the development of an imageprocessing based toolnamed PostureCheckaimed at automatically detecting when patients perform undesirable compensatory movements during robot assisted upper limb rehabilitation exercisesThe system will be based on a standard video camerae gGoProthat will be used to capture the movements of ...

Measurement of cervical dilation during late pregnancy and labor informs decisions in the management of labor and deliveryPrior published research suggests that practitioners are onlytoaccurate when judging cervical simulatorsWhen measuring laboring womentwo practitionersandaposmeasurements agree onlyof the timeDrEva Martin of Elm Tree Medical Incdeveloped a novel deviceDilaCheckto enable practiti ...

Ensuring access to clean water for generations to come will involve developing novel approaches to determining the safety and composition of potable water that are practical and affordableArsenicmercuryand cadmium are three of the top priorities among hazardous substances commonly found at Superfund sitesas they are linked to health problems in people exposed to them in drinking wateryet the curre ...

ABSTRACTLogicInk will design and develop a discretelow costwearable alcohol sensor that works via detection of ethanol in sweat and requires no power supplyThe wearable device will let users better understand the impact of their drinking habits on their bodyas reflected by alcohol concentration levels over timeThese discreteelectronics free wearables that resemble temporary tattoos will change col ...

ABSTRACT Venous access is the most commonly performed invasive medical procedure with overmillion peripherally inserted venous cathetersPIVCused annually in the US andbillion globallyHoweverthe rate of failure prior to completion of therapy remains unacceptably high atSuch alarmingly high rate of PIVC failure is primarily attributable to overpenetration through the back wall of the vein resulting ...

The long term goal of this proposal is to develop a safeeffective and user friendly vitrification system for cryopreservation of whole human ovariesIn the U Sovergirls and women ageare diagnosed with cancer annuallyWhile improved diagnosis and treatment have led to increased survival ratesin premenopausal andin childhood cancer patientsdevastating side effects of cancer therapies include premature ...