Award Data

The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase II project is the reduction of greenhouse gas (GHG) emissions by replacing plastics with cellulose secreted by genetically modified bacteria in the form of synthetic leather. This substitution effort will assist the USA in reaching net-zero GHG emissions by saving over 660 million metric tons of carbon dioxide (C ...

Abstract Despite progress in immunotherapies, there are significant challenges to overcome to make them more broadly applicable to different cancers and more effective for patients. However, current efforts to improve adoptive cell therapies and immune checkpoint blockade as well as cancer vaccines are hampered by the lack of a method to characterize the functional and phenotypical changes of diff ...

PROJECT SUMMARY / ABSTRACT There are more than 230,000 new cases of lung cancer and over 130,000 deaths due to lung cancer each year in the U.S. Approximately 120,000 people each year will present with metastatic Non-Small Cell Lung Cancer (mNSCLC) for the first time, and only 7% of these patients will survive five years or more. accurius is developing the first of a kind inhalable agent that will ...

Project Summary/AbstractProteasome inhibitors (PIs) are one of the most important classes of therapeutics to have emerged in the past two decades and now serve as the backbone of multiple myeloma (MM) treatment. The first-in-class PI, bortezomib (Btz), targets the ubiquitin proteasome pathway (UPP), which has led to tremendous efficacy in inducing plasma cell apoptosis and in inhibiting MM growth. ...

One of the goals of DOE’s MPACT program is to develop nuclear material accounting (NMA) methods for next generation, advanced fuel cycles such as Molten Salt Reactors (MSR). There are several challenges for NMA of MSR, for example, the high temperature and high dose rates, at which the measurements need to be performed. The goal of the proposed research is to develop high-count-rate, high temper ...

The trafficking of special-nuclear material (SNM) and radiological sources remains a serious threat to the security of the United States. To counter nuclear trafficking, the Department of Homeland Security (DHS) relies on Radiation Portal Monitor’s (RPMs) that scan vehicles and cargo containers across U.S. points of entry for radiation signatures. The current RPMs predominantly consist of polyvi ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is improved access to 3D x-ray imaging in everyday life. Currently 3D x-ray imaging is used for applications where it is absolutely necessary to non-destructively image an object. One example is in healthcare, known as computed tomography, where imaging is performed 250,000 times per day in th ...

This proposal seeks the development of analog AI training processors with more than 240× performance to push the boundaries of AI without spending billions of dollars to train each new advanced model, or worse, burning down the entire planet. The building blocks of these architectures will be the novel class of nanoprotonic devices with ideal characteristics we will develop here, such that the re ...

This proposal seeks the development of analog AI training processors with more than 240× performance to push the boundaries of AI without spending billions of dollars to train each new advanced model, or worse, burning down the entire planet. The building blocks of these architectures will be the novel class of nanoprotonic devices with ideal characteristics we will develop here, such that the re ...

Foundation Alloy integrates material design and part production by developing a new class of nanostructured alloys specifically engineered for powder metallurgy-based processing through 3D printing and sintering. Foundation Alloy is developing a design platform for new alloys that combine unprecedented performance with a unique suitability to today’s advanced manufacturing techniques. Foundation ...