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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Miniaturized Distal Vibration System for Penetration of Vascular Occlusions

    SBC: FRANTZ MEDICAL DEVELOPMENT LTD            Topic: NHLBI

    DESCRIPTION (provided by applicant): Chronic total occlusions (CTOs), defined as vessels that have been completely occluded for 3 months, are a prevalent vascular disease found in about one-third of patients undergoing a coronary angiogram and in 30-50% of peripheral procedures. Revascularization of CTOs offers important benefits to the patient including reduced angina symptoms, improved left vent ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Discovery of drugs for use in the treatment and prevention of HIV infection using

    SBC: SYMBION DISCOVERY INCORPORATED            Topic: NCCAM

    DESCRIPTION (provided by applicant): Natural products are still the majority of therapeutic agents. However, they suffer from a difficulty in the creation of derivatives, and they can also be hard to supply. Derivatives are extremely important in the optimization of properties, such as toxicity or solubility, that are critical to development of therapeutics. Recently, it has become increasingly po ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Not Available

    SBC: KDT, LLC            Topic: NIEHS

    Toxic compounds are a major health hazard in our environment, in our food, and in our pharmaceuticals. Identifying toxic compounds is currently time-consuming, expensive and complicated by animal rights issues. We propose to generate a set of 96 transgenic nematodes that will contain fluorescent constructs that can measure activation of specific pathways. These strains can be used to categorize ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Subcellular imaging of biochemical processes within human retina

    SBC: Polgenix, Inc            Topic: NEI

    DESCRIPTION (provided by applicant): Our long-term goal is to develop a clinical instrument, the 2-photon ophthalmoscope, for non-invasive, high-resolution and repetitive imaging of biochemical processes within the human retina. Such an instrument will have tremendous potential for early detection of age and disease related changes in the eye, long before pathological manifestations of retinal di ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Not Available

    SBC: LEADSCOPE, INC.            Topic: NIEHS

    The last two decades have produced dramatic technological advances in molecular biology and computer science. The NTP is evaluating how best to incorporate these advances into its research and testing strategies in order to broaden scientific knowledge of exposure-related disease mechanisms. To support these efforts, the goal of this contract is to develop a PC and/or Mac-based integrated predi ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Targeted Polymeric Combination Delivery for Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of a polymeric delivery system that will deliver two anticancer drugs with diverse mechanisms of action simultaneously into ovarian cancer cells. The delivery system will be composed of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer as the backbone. It i ...

    STTR Phase I 2010 Department of Health and Human Services
  7. Optimization of Protein Therapeutic Formulations

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This proposal involves the development and validation of a novel approach to improve and accelerate the discovery of biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infectious and chronic diseases. The proposed research is intended to establish a new paradigm for rapidly ...

    STTR Phase I 2010 Department of Health and Human Services
  8. Fluorescence Intensity-Based Scoring of Macromolecule Crystallization Plates

    SBC: IXPRESSGENES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

    STTR Phase I 2010 Department of Health and Human Services
  9. In Vivo Assessment of Embryonic Stem Cell Teratoma Prevention

    SBC: BIOINVISION INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. Researchers at Case Western Reserve University and BioInVision, Inc. will join together to create platform technologies for validating existing embryonic stem ce ...

    STTR Phase I 2010 Department of Health and Human Services
  10. Small Molecule targeting of NADPH oxidase in neutrophils

    SBC: P2D, INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are characterized by a rapid and severe respiratory failure, arising after clinical events including major surgery, trauma, multiple transfusions and sepsis. ALI/ARDS have an associated mortality of 40-80% and current pharmacological modalities have been unsuccessful in decreasing mortality. ...

    STTR Phase I 2010 Department of Health and Human Services

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