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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Care Assistant for Family Caregivers of Persons with Dementia During Out of the Home Activities

    SBC: Koronis Biomedical Technologies Corp.            Topic: R

    Abstract Increases in life expectancy together with demographic trends have fueled a rapid increase in America’s elderly population. As the number of older Americans has grown, so has the prevalence of aging-associated diseases, including Alzheimer’s Disease (AD) and other related dementias (ADRD). An estimated 5.4 Million Americans had AD in 2012, and that number is expected to double by 2030 ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. App-Assisted Day Reconstruction to Reduce Treatment Burden and Logistic Toxicity in Cancer Patients

    SBC: Daynamica Inc.            Topic: NCI

    PROJECT SUMMARY Each year, more than 1.7 million new cancer patients in the U.S. undergo intense, multimodal treatments that that create numerous logistical challenges in managing treatment and everyday life priorities. In the current cancer care system, “logistic toxicity”—the toxic effects imposed by the logistical burden of carrying out cancer treatment-related tasks on patient well-being ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. An Integrated Neurochemical/Electrophysiological Recording and Neuromodulation System for Basic and Clinical Research

    SBC: Wincs International, LLC            Topic: 107

    PROJECT SUMMARY WINCS International LLC, in partnership with Mayo Clinic, proposes to develop and demonstrate a highly innovative next-generation clinical instrument together with custom user-friendly display and analysis software. For the first time, the Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN) will offer wireless voltammetric sensing of multiple n ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Development of the UValidate platform for the profiling of topically applied chemical agents.

    SBC: AMELIA TECHNOLOGIES LLC            Topic: R

    Project Summary Skin is the first line of defense against the outside environment. When the skin barrier is breached by UV irradiation (UVR) or toxic chemicals, living cell layers including epidermal keratinocytes, melanocytes and dermal fibroblasts are subjected to DNA damage. If unrepaired, this damage can lead to photoaging and cutaneous carcinogenesis. In fact, skin cancer is by far the most c ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Development of (R,S')-MNF as a dual-targeted therapy for pancreatic cancer

    SBC: PAZ PHARMACEUTICALS LLC            Topic: NCI

    Summary Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the U.S. with a 5-year survival rate of andlt;9%. The poor prognosis is partially due to resistance to standard of care treatments including gemcitabine (Gem) and Gem+nab-paclitaxel (n-PTX). The transcription factors HIF-1α and c-MYC are at the center of the mechanisms producing Gem and n-PTX resistance ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. A novel CAR-T cell therapy for the one-time treatment of chronic HIV infection in patients who are not ART suppressed

    SBC: MARPAM PHARMA LLC            Topic: NIAID

    Abstract Building on our successful primate model studies, we aim to develop a one-time treatment for durable remission of human immunodeficiency virus (HIV) in the absence of antiretroviral therapy (ART). This targeted treatment is an autologous HIV-specific chimeric antigen receptor (CAR)-T cell therapy that employs a CXCR5 “homing device” to direct anti-viral killer T cells into B cell foll ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. 3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology

    SBC: Applied Universal Dynamics, Corp.            Topic: 102

    PROJECT SUMMARY This proposal responds to PAR-18-870 titled “BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR).” This project is a Fast Track STTR with a phase I and phase II. The small business, Applied Universal Dynamics Corp. (AUD) is collaborating with the University of Minnesota (U of MN). The activity patterns of t ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Early detection and monitoring of Alzheimers Disease and Related Dementias using non-semantic linguistic and acoustic features of speech derived from hearing aids

    SBC: BISCHOFF HOLDINGS INC            Topic: NIA

    Abstract Alzheimer’s disease and related dementias (ADRD) are a serious national health concern that affected 5.8 million in 2020 and are expected to increase by 40% over the next decade. There is evidence that the functional, psychological, pathological, and physiological changes underlying ADRD may emerge many years prior to the clinical manifestation of cognitive symptoms, which is increasing ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 433: A FEDERATED DATA PLATFORM FOR DEVELOPING UNBIASED BREAST IMAGING AI

    SBC: FLYWHEEL EXCHANGE, LLC            Topic: 433

    This SBIR project aims to implement a federated data platform focused on a data system to enable mammography data to be published into a federated catalog from which collaborators can execute federated analyses. It will enable hospitals and other clinical entities to make their data available for training and validation of artificial intelligence applications. The data federation will include a ra ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. DEVELOPING A NOVEL NON-VIRAL NANOPIECES GENE DELIVERY SYSTEM FOR AD GENE THERAPY

    SBC: Nanode Therapeutics, Inc.            Topic: 4

    To develop a new, safe, and efficacious non-viral gene delivery system crossing the blood-brain barrier (BBB) for gene therapy of Alzheimer’s Disease (AD).

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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