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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 51 - 60 of 3340 results
  1. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Tablet-Based Augmented Reality for Fast CT Guidance with Reduced Radiation

    SBC: Clear Guide Medical, Inc.            Topic: 101

    Clear Guide MedicalIncSummary In an earlier Phase II SBIRTopic NumberSBIRHHSNCRFPNCClear Guide Medical developed the Clear Guide SCENERGYa compact guidance system for CTultrasound fusion and easy instrument guidanceBuilding on this fundamental technologyClear Guide Medical proposes to make the SCENERGY CT onlywithout the use of real time ultrasoundFeedback from potential customers in interventiona ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Chemoenzymatic synthesis of stable isotope-labeled glycopeptides as internal standards for glycosylation quantitation

    SBC: Glycot Therapeutics, LLC            Topic: 300

    AbstractIn this applicationwe propose to apply a novel chemoenzymatic method developed by ProfLai Xi Wang at University of Marylandbeing licensed to GlycoT Therapeutics LLCto construct a focused library of stable isotope labeled Fc glycopeptides of IgG subclasses IgGwhich will be highly valuable as standards for absolute quantification of Fc glycosylation changes in human sera from patients and fo ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. TB Diagnostics at the Point of Care


    ABSTRACT Tuberculosis ranks in the top ten worldwide cause of death and now ranks ahead of HIVmaking it the number one infectious disease killerPerhapsmost alarming is the global prevalence of multidrug resistant TBMDRTBand extensively drug resistant TBXDR TBmore thanof new TB cases are MDR TB andof these have XDR TBAndthe number of enrolled XDR TB cases has grown fromcountries intoinThe concern t ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. A robust heterologous expression system of intact fungal secondary metabolite gene clusters for natural product discovery in Aspergillus nidulans

    SBC: Intact Genomics Inc.            Topic: NCCIH

    PROJECT SUMMARY The economic and social burden for the treatment of chronic and infectious diseases is enormousandgt $BThe emergence of drug resistant microbesthe diminishing supply of novel classes of antibioticsand the dramatic reduction in discovery and development of anti infectiveanti proliferation and anti inflammation agents have further amplified public health concernFungi are prolific pro ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Novel Long Acting rhTSH Superagonist Analogs for Improved Diagnostic Imaging, Thyroglobulin Stimulation and Therapy of Thyroid Cancer.

    SBC: TROPHOGEN INC            Topic: 102

    PROJECT SUMMARYABSTRACT Thyroid cancer is the most common malignancy of endocrine tissuesdisproportionally affecting womenand is one of the few cancers greatly increasing in incidence andampprevalence for unknown reasonsA very aggressive form of this cancer may result from nuclear accidents like Chernobyl andampFukushimaincreasing proximity of nuclear waste storage sitesor from nuclear explosions ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Targeting Hepatocyte Growth Factor Processing and Activation in Lung Cancer

    SBC: ProTexase Therapeutics, Inc.            Topic: 102

    ABSTRACTInnate or acquired resistance represents a major limitation of targeted cancer therapyThe broader goal of this application is to develop drugs that prevent resistance to targeted therapy in lung cancer patientsIn addition to cell autonomous mechanisms of resistancefactors in the tumor microenvironment have been shown to block the response to therapyThe microenvironment mediated resistance ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Development of Fibrin-Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiologythe prognosis for patients with severemedically refractive heart failureHFis exceedingly poorApproximatelydeaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizationsAt leastof these deaths were directly related to severe heart fai ...

    STTR Phase II 2018 Department of Health and Human Services
  10. Virtual Training Role-Plays to Improve Patient Suicide Outcomes in Primary Care Settings

    SBC: SIMmersion L.L.C.            Topic: 104

    ABSTRACT SIMmersionin collaboration with the Institute for Family HealthIFHand the Educational Development CenterEDCpropose to develop a web based training productSuicide Prevention Role plays for Interactive TrainingSPiRITa series ofmodules to train providers to more effectively manage patients who screen positive for risk of suicide in this Phase I Phase II fast track applicationIf fundedthe tea ...

    SBIR Phase II 2018 Department of Health and Human Services

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