Award Data

Abstract This proposal responds directly to the PAR-21-225 Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models. While it is standard practice to continuously monitor the health of human patients following a major surgery, this is typically not the case for monitoring recovery in rodent pre- clinical research. For example, it is common practice that rats and ...

Project Summary Metastatic prostate cancer is a notoriously heterogeneous disease that is difficult to treat. The five-year survival rate has not improved over the past twenty-five years and the median survival rate for those diagnosed with metastatic castration resistant prostate cancer (mCRPC) is only 15-36 months. Precision medicine has the potential to improve mCRPC outcomes. Transciptomic seq ...

PROJECT ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and fatal fibrotic lung disorder which disproportionately affects men and the elderly. Although two drugs (pirfenidone and nintedanib) have recently gained FDA-approval for IPF and progressive fibrosing lung disorders related to connective tissue diseases (rheumatoid arthritis and scleroderma, more common in younger ...

Project Summary Obsessive-compulsive disorder (OCD) is characterized by intrusive, distressing thoughts (obsessions) in response to which an individual feels compelled to perform a repetitive behavior (compulsions), which are performed in order to reduce the acute distress experienced by the patient but which perpetuate OCD symptoms. Effective treatment requires accurate reporting of compulsive be ...

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease. Initially, PAH develops asymptomatically or with mild symptoms that are often unrecognized by primary doctors. However, even after the onset of non-specific symptoms, such as dyspnea on exertion and fatigue, PAH remains unrecognized for ≥two years. On average, it takes a patient five visits to a general practitioner, and t ...

PROJECT SUMMARY Klebsiella pneumoniae is an encapsulated human pathogen capable of causing a myriad of human infections. Recently, K. pneumoniae has also emerged as one the most common causes of secondary bacterial pneumonia in COVID-19 patients. Over the last 40 years, K. pneumoniae has evolved into two distinct pathotypes, known as classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (h ...

ABSTRACT Acute respiratory distress syndrome (ARDS) is a critical illness with 30- 40% mortality and currently there are no FDA-approved therapies. Quell Pharma and Aqualung Therapeutics have developed a recombinant soluble, cell-free form of recombinant human P-selectin glycoprotein ligand-1 (PSGL-1) designated Tandem P-Selectin glycoprotein ligand-1 immunoglobulin (TSGL-Ig), which is a potent pa ...

Project Summary/Abstract Lysosomal proteolysis facilitates the turnover of organelles and selected long-lived proteins and is a critical regulator of cellular homeostasis. Its aberrant activation promotes drug resistance and cancer progression by generating alternative sources of survival sustaining metabolic fuel to cells that are stressed by hypoxia, radiation, chemotherapy, and targeted agents. ...

PROJECT SUMMARY Staphylococcus aureus is an aggressive antibiotic-resistant human bacterial pathogen. S. aureus is a leading cause of infectious disease morbidity, mortality, and hospital-associated infection in the U.S., and a formidable health threat worldwide. Given the rapid acquisition of drug resistance by S. aureus, universal vaccination has been a premier goal in the field to provide a dur ...

PROJECT SUMMARY Each year, more than 1.7 million new cancer patients in the U.S. undergo intense, multimodal treatments that that create numerous logistical challenges in managing treatment and everyday life priorities. In the current cancer care system, “logistic toxicity”—the toxic effects imposed by the logistical burden of carrying out cancer treatment-related tasks on patient well-being ...