Award Data

DESCRIPTION (provided by applicant): Methyltransferases (MTs) are a diverse class of enzymes that catalyze the transfer of a methyl group from S-adenosylmethionine (SAM) to a substrate molecule. MTs catalyze reversible covalent modifications of proteins aswell as a variety of biological molecules, including proteins, such as histones, as well as DNA, RNA, hormones, lipids and metabolites. Over 200 ...

DESCRIPTION (provided by applicant): The overall goal for this project is to design a compact cryocooling device for fast, reproducible and reliable cryopreservation of protein and virus crystals for X-ray cryocrystallography. X-ray crystallography is themost powerful and widely used tool for determining the molecular structure of proteins, viruses, nucleic acids and biomolecular complexes. Flash- ...

DESCRIPTION (provided by applicant): The primary goal of this proposed research is to develop a rapid point-of-care (POC) test that can be used to identify neonatal sepsis in high-risk infants in a simple, user-friendly and portable device suitable for usein the NICU setting. Since sepsis presents a very serious threat to neonates, there is an urgent need to obtain confirmation as soon as possible ...

DESCRIPTION (provided by applicant): Cognitive deficits associated with neurodevelopmental disorders, neurodegenerative diseases, and learning disabilities affect the independence and well-being of tens of millions of Americans. Recent research in the fields of neuroscience and psychology suggest new techniques to improve learning and memory by enhancing memory consolidation processes active durin ...

DESCRIPTION (provided by applicant): VoxelDiscovery 5-8: Engaging the Middle Grades in Visualization of the Nervous System proposes to empower middle school students to use modern neuroimaging research to explore questions relevant to young adolescents lives and health, such as: (1) Are all people wired the same way?; (2) How is my brain changing as I grow up and why do I think the way I do?; (3) ...

DESCRIPTION (provided by applicant): Every gene has its own set of small RNA molecules, known as small interfering RNA (siRNA), that inhibit expression of the gene's proteins. The siRNA molecules are part of an ancient natural mechanism of gene regulation,known as RNA interference (RNAi) that has been evolutionarily conserved since the earliest eukaryotic cells. More recently researchers have ...

DESCRIPTION (provided by applicant). Several leading authorities, including the World Health Organization (WHO) and the U.S. Department of Health and Human Services (DHHS), have identified asthma as a priority disease area, and have called for action to reduce chronic disability and premature death due to asthma, to enhance HRQOL through education and improved asthma management techniques, and to ...

DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a progressive, agonizing, debilitating and routinely fatal disease that afflicts 200,000 individuals in the United States and five million patients worldwide. There are currentlyno effective treatments available for this devastating illness. Although the etiology of IPF is currently unknown, various insults ar thought to ...

DESCRIPTION (provided by applicant): Childhood obesity is a serious public health issue with significant health risks and high medical costs. Using motivational interviewing (MI) around nutrition and physical activity in the context o an office visit has shown positive results in terms of health behavior change and weight lost in both the pediatric and adult populations. Despite studies ...

DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the treatment of MI via use as adjuvant to recanalization therapy. However, clinical administration of rhH2 ...