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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Universal Flu Vaccine Based on Conformationally Locked Soluble Headless HA

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant An influenza pandemic remains an acute threat to world health and stockpiling a universally protective influenza vaccine provides a strong defense against this potential catastrophe The hemagglutinin HA protein is the primary target of humoral Ab responses to Influenza Vaccines based on full length HA give rise predominantly to strain specific Ab response ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Balancing Immunogenicity of a Tetravalent Live Attenuated Dengue Vaccine

    SBC: Codagenix Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Dengue virus DENV infections are the leading mosquito borne human viral diseases in the world with billion people at risk of infection The diseases caused by DENV range from a self limiting Dengue fever DF to the life threatening hemorrhagic DHF and capillary leak syndrome Dengue shock syndrome DSS DENV accounts for possibly million infectio ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization of Supercritical Carbon Dioxide Based Virus Inactivation, Characterized by Protein Damage and Maintenance of Epitope Integrity in Vaccine Sterilization

    SBC: NOVASTERILIS            Topic: NIAID

    DESCRIPTION provided by applicant The process combining supercritical CO and co sterilants produces strong synergistic microbicidal effects in relatively mild conditions The mechanism of microbe inactivation is not well characterized but the disruption of lipid membranes and mild oxidative damage appear to be involved The process which is also highly efficient against viruses is considere ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Sporocidal Mechanism and Inline Monitoring of Peracetic Acid in Supercritical CO2

    SBC: NOVASTERILIS            Topic: NIAID

    DESCRIPTION provided by applicant It is critical to sterilize biomedical devices xenograft and allograft materials due to the rapid rise of antibiotic resistance in hospital acquired infections HAI For one major HAI pathogen Clostridium difficile the use of antibiotics promotes greater infection rates and worse outcome as the native intestinal flora is eliminated by the strong antibioti ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Molecular Diagnostic Test For Early Onset of Lyme Disease

    SBC: BIOSCIENCE DEVELOPMENT INC            Topic: NIAID

    DESCRIPTION provided by applicant There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelae Diagnosis is often difficult because most symptoms are often nebulous with the telltale andquot bulls eyeandquot rash only appearing and clearly recognizable in approximately half of c ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. NOVEL ULTRASENSITIVE CANCER BIOMARKER ASSAY PLATFORM UTILIZING PALLADIUM CATALYZED HIGH-GAIN CHEMICAL AMPLIFICATION

    SBC: CATASSAYS            Topic: NCI

    DESCRIPTION provided by applicant We propose to use CatAssaysandapos novel Palladium Catalyzed Chemical Amplification PdCCA technology platform to develop ultra sensitive sandwich ELISA format bioassays to detect very low concentrations of a number of critical cancer and immunoregulatory biomarkers CatAssaysandapos PdCCA technology the first example of the application of heterogeneous me ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Minimally Invasive Surgical Device for the Treatment of Esophageal Cancer

    SBC: CELL PRESERVATION SERVICES INC            Topic: NCI

    DESCRIPTION provided by applicant The treatment of Esophageal Cancer has experienced a palpable increase in the last few years While numerous options are currently under investigation many if not all remain suboptimal This is critical as it is estimated that in there were new cases and over deaths from esophageal cancer worldwide In the US alone there were new ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Durable Biomechanical Stabilization of Spinal Fusion Segments Despite Pseudoarthrosis Using Spinal Implants with Nano and Micron Porous Hierarchical Structures in a Novel Non-Union Model

    SBC: NANOVIS, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant The team proposes to evaluate and commercialize an innovative technology platform capable of stabilizing a spine segment despite non fusion pseudoarthoris To do that the team proposes to complete development of i a customized titanium dioxide nanotube surface for optimized osseointegration ii a micro porous titanium scaffold coated PEEK substrate to all ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Therapeutic Role of Inter-alpha Inhibitors in Wound Healing

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant Wound healing is an intricately regulated process broadly characterized by phases of inflammation proliferation and remodeling Imbalances in any one of these phases can result in inadequate healing scar formation or in the development of chronic wounds such as diabetic ulcers Diabetic ulcers are responsible for the majority of lower extremity amputations ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Infrared-activated promoter for gene therapy of arthritis.

    SBC: LOCALIZED THERAPEUTICS LLC            Topic: NIAMS

    DESCRIPTION provided by applicant Infrared activated promoter for gene therapy of arthritis It is fair to generalize that unfortunately more patients currently die from toxicity of medications than from disease Although gene therapy is a promising alternative to small molecule drugs allowing to produce biologics inside the body and to reduce costs of treatment its progress has been stalled d ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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