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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Human hepatocytes for drug toxicity screening from Cardiac Death Donor livers

    SBC: HEPATOSYS INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Liver toxicity is a major barrier to the FDA approval of many new drugs. Moreover, since the liver is the major site of metabolism of most xenobiotics it is essential to know how the liver metabolizes new drug. Becauseof the many species differences between humans and commonly used animal models, testing on human hepatocytes remains the gold standard for drug s ...

    SBIR Phase I 2012 Department of Health and Human Services
  2. Development of a Drug Discovery Platform for Human Islets

    SBC: ZEN-BIO, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Diabetes and diabetes-related co-morbidities are at epidemic proportions and an enormous burden to our healthcare system. Although there has been significant progress in defining the causative factors and molecular mechanisms involved in both type 1 and type 2 diabetes, it remains an overwhelming challenge to identify efficacious therapeutic modalities. Novel a ...

    SBIR Phase I 2012 Department of Health and Human Services
  3. Integration of Genomic Biomarkers with the devTOX Human Embryonic Stem Cells Scre


    DESCRIPTION (provided by applicant): Current assays employed to assess the potential of drugs and environmental agents for their potential to cause birth defects involve the use of animal models. Not only are these models costly and time consuming, but they also have poor concordance to human data. SteminaTM Biomarker Discovery (Stemina) has developed a screening assay that utilizes human embryoni ...

    SBIR Phase I 2012 Department of Health and Human Services
  4. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics

    SBC: BIOPTIGEN, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Dry Eye disease is an affliction that impacts as many much as 20% of the U.S. population over age 50, and is even more prevalent in the Asia Pacific. Dry eye therapies are currently a 1.7B market, growing at 10% annually. Treatment is primary palliative, involving warm compresses and eye drops. TearScience recently released LipiFlow to thermally improve meibom ...

    SBIR Phase I 2012 Department of Health and Human Services
  5. Peptide-coated skin substitutes for the treatment of burn injuries and wounds

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Burn injuries and chronic wounds present a significant burden to patients and the US healthcare system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization. One of the most common causes of chronic wounds, venous ulcers, occurs in 600,000 to 1,500,000 US patients; 15% to 20% of patients with ...

    SBIR Phase I 2012 Department of Health and Human Services
  6. Use of a Nitric Oxide-Loaded Gel to Improve Healing Outcomes of Burn Injuries

    SBC: Novan, Inc.            Topic: NIGMS

    DESCRIPTION: Globally, an estimated 322,000 individuals die from fire-related burn injuries each year. In the United States, 450,000 experience burns requiring hospitalization and 3,500 of these lead to fatal outcomes. A burn of 30% of total body area cancost as much as 200,000 in initial hospitalization costs, not including the additional costs for repeat admission for reconstruction and for reh ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Rapid detection of neonatal sepsis


    DESCRIPTION (provided by applicant): The primary goal of this proposed research is to develop a rapid point-of-care (POC) test that can be used to identify neonatal sepsis in high-risk infants in a simple, user-friendly and portable device suitable for usein the NICU setting. Since sepsis presents a very serious threat to neonates, there is an urgent need to obtain confirmation as soon as possible ...

    SBIR Phase I 2012 Department of Health and Human Services
  8. An infrared camera tracking system for a motivational device to develop posture c


    DESCRIPTION (provided by applicant): This Phase I Small Business Innovation Research (SBIR) proposal seeks to develop an innovative, inexpensive, and reliable system, called the Tummy-Time Motivator (TTM), to motivate children to improve postural control.Postural control is the foundation for the development of skilled actions such as locomotion and balance, and it enables children to interact mor ...

    SBIR Phase I 2012 Department of Health and Human Services
  9. Parent Education and Resources for Self-Injurious Youth

    SBC: 3-C Institute for Social Development, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) is an increasingly common self-harming behavior among adolescents and young adults, with current estimates of NSSI in youth ranging from 12-37%. Although NSSI is associated with other mental health problems (e.g., depression, anxiety, disordered eating) and is a risk factor for suicide and severe unintended injury, evidence-based ...

    SBIR Phase I 2012 Department of Health and Human Services
  10. Multiplex platform for point of care newborn screening of hyperbilirubinemia


    DESCRIPTION (provided by applicant): Jaundice is the most common condition that requires urgent medical attention in some newborns and is the result of elevation in circulating unconjugated bilirubin. The unbound unconjugated bilirubin can be specificallyneurotoxic and, if untreated, is associated with irreversible lifelong neurological damage. This condition is the most easily preventable cause o ...

    SBIR Phase I 2012 Department of Health and Human Services

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