Award Data

Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...

PROJECT SUMMARY Drugs act by altering the activities of particular componentstargetswithin a cell or organismThusdrug discovery campaigns begin by identifying a targetfollowed by screening this target with compounds to identify leads that can be developed into a drugUnfortunatelyidentifying effective drug targets for a given diseaselet alone for individual patientse gin highly heterogeneous cancer ...

Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...

Project Summary Abstract Miami has emerged as the US epicenter of the now global Zika virusZIKVepidemicThe consequences of infection remain to be fully elucidatedbut the probable link between ZIKV infection and fetal developmental complications raises enormous concern as to the potential impact of ZIKVCurrent emergency use authorizationEUAcommercial assays detect ZIKV RNAthe presence of ZIKV speci ...

Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...

Summary Abstract The ultimate goal of this project is the validation of a humanized endothelial monocyteactivating protein IIEMAP IIneutralizing monoclonal antibodymAbfor progression to clinical evaluation as a novel treatment for patients with influenza associated lung injuryInfection with influenza virusIAVremains a major world wide health threat to high risk populations including the young and ...

Project Summary This project will develop newD visualization to improve stent graft deployment during minimally invasive endovascular aortic repairEVARby overcoming limitations ofD x ray fluoroscopyfluoroD holographic guidancenavigation and controlD GNandamp Cwill be provided to decrease fluoro radiation dose burden to patients and OR staff during treatment of aortic aneurysmsparticularly when dep ...

Abstract E cigaretteE ciguse has rapidly proliferated worldwideIt is speculated that E cig use may exceed conventional cigarette use withinyearsCigarette smoking is the leading preventable cause of death and disabilityAs E cigs are a relatively new productstudies are needed to determine their long term detrimental effectssome of which may be similar to the long term detrimental effects of nicotine ...

State of the art techniques in Developmental and Reproductive Technology use slowexpensive testing of pregnant female rodentsor of embryonic stem cellsESCsthat are cultured to lose stem cell qualities and differentiate into organ tissuesThis only produces toxicological outcomes similar to those in adult versions of these organsReproductive StressM has established high throughput screensHTSsthat te ...

In this proposal we support the development of a hypoxia test battery by designing and developing a domain general tool suite for processing, synchronizing, and evaluating data from cognitive, behavioral, and physiological measures.The proposed Griffon Tool Suite addresses many of the practical requirements demanded by a flexible test battery. The effort falls into three major thrusts.First, we pr ...