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SBC: ADVANCED MEDICAL ELECTRONICS CORP Topic: NIA
DESCRIPTION provided by applicant Insomnia of sufficient clinical severity to meet diagnostic criteria is present in approximately of older adults nearly million individuals n the US alone If left untreated it can lead to increased rates of depression cognitive impairment and cardiovascular disease Treatment relies on pharmacotherapy such as sedative hypnotic therapy which is ass ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: H-CUBED Topic: NHLBI
DESCRIPTION provided by applicant Congenital diaphragmatic hernia CDH affects in newborns CDH is a disorder in which part of the diaphragm fails to form allowing abdominal organs to migrate into the chest resulting in lung hypoplasia underdevelopment in affected infants Although great strides have been made in the management of this disease significant morbidity and mortality p ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Development of a novel platform to enhance intracellular bioavailability of antisense morpholino oligomersSBC: NAJIT TECHNOLOGIES INC Topic: NIAID
DESCRIPTION provided by applicant Peptide conjugated phosphorodiamidate morpholino oligomers PPMO are single stranded nucleic acid analogs able to modulate gene expression through steric blocking of complementary RNA PPMO are composed of two components an antisense morpholino oligomer cargo covalently conjugated to a cell penetrating delivery peptide PPMO are completely nuclease resistant ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: KLEIN BUENDEL, INC. Topic: NIMHD
DESCRIPTION provided by applicant African American men experience health disparities across a number of preventable chronic diseases including cardiovascular disease strokes obesity and diabetes Physical activity PA is a modifiable risk factor for these conditions The few PA promotion studies that have included African American men have resulted in successful short term behavior change ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: TDA RESEARCH, INC. Topic: NIAID
Project Summary Abstract Development of Optimized Endectocide treated Bird Feed Formulations for West Nile Virus Control STTR Phase I Application PIs Brady Clapsaddle TDA Research Inc Dr Brian Foy Colorado State University West Nile Virus WNV is the leading cause of domestically acquired arboviral disease in the United States resulting in significant disease and death every year in both ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: LIFE SERVICES L.L.C. Topic: 101
DESCRIPTION provided by applicant For this Phase I STTR proposal the investigators plan to develop the radiofrequency RF coil technology required for high resolution fMRI at T In the absence of a body transmit coil all T head coils must also incorporate a transmitter in addition to the receiver Here we propose a transmit array with up to individual channels combined with a receive a ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Novel Assay System and Analysis Algorithm in Detecting RNA Editing Events and Linked Splicing IsoformsSBC: Celetrix LLC Topic: NIDA
Abstract RNA editing is a process in which the genome encoded information is altered in RNA RNA editing is an efficient way to increase RNA complexity thereby fine tuning both gene function and dosage Adenosine to Inosine A to I editing is the most common type of RNA editing known in animals The cellular machinery recognizes inosine as guanosine so A to I editing of codons and splicing sign ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Epigenetix Inc Topic: R41
PROJECT SUMMARY This proposal aims to develop a new small molecule drug to be advanced into human clinical trials for the treatment of cocaine addiction According to the National Institute on Drug Abuse illicit drug use cost the United States more than $ billion annually in expenses related to crime lost work productivity and health care Approximately million Americans aged or older ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC Topic: NIGMS
Commercial Polymerases to Create Receptors Ligands and Catalysts on Demand Firebird Biomolecular Sciences LLC University of Texas Steven A Benner Andrew D Ellington ABSTRACT Innovators at Firebird Biomolecular Sciences LLC have created several generations of an artificially ex panded genetic information system AEGIS that adds eight nucleobases that form four additional pairs Z P S ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
"Speed Bumps": A non-invasive quantitative test for early detection of neuropathy in the feetSBC: Neuro Devices, Inc. Topic: 101
ABSTRACT This STTR Phase I resubmission describes a small deceptively simple portable device called Speed Bumps that rapidly quantifies the sensation of flutter on the feet toes or fingers in micrometer m units Flutter frequency is to Hz which is below the approximate lower vibration range of to Hz This high sensitivity device is designed to differentiate the small variati ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health