Award Data

CURRENTLY, THE VITREOUS COMPARTMENT OF OWL MONKEYS IS USED TO EVALUATE VISCOELASTIC HYALURONAN OPHTHALMIC MEDICAL DEVICES BEFORE USE IN HUMANS. TO DATE, NO TEST OTHER THAN THE MONKEY VITREOUS TEST (MVT) HAS BEEN ABLE TO PREDICT, WITH THE REQUIRED CONSISTENCY, THE INFLAMMATORY/NONINFLAMMATORY NATURE OF HA MATERIALS. IT WOULD BE ADVANTAGEOUS TO HAVE A RELIABLE ALTERNATIVE THAT COULD PREDICT THE NATU ...

DESCRIPTION (provided by applicant): Molecular recognition is the underlying principle in many biomedical applications, such as labeling and imaging specific proteins, organelles, cells, tissues and organs, detecting and quantifying clinical analytes, and discovering target-specific drug candidates. Currently, the primary technology for identifying research and diagnostic ligands is monoclonal ...

More thanmillion Americans have such severe COPDchronic obstructive pulmonary diseasethat they cannot even climb a single flight of stairsdue to the feeling of suffocation with even minimal movementThese patients suffer like this for yearsfirst becoming essentially home boundthen chair boundand eventually bed boundThis lack of physical activity has been repeatedly shown to increase the frequency o ...

Project SummaryProtein phosphorylation plays an essential role in orchestrating the myriad aspects of cell functionKinaseswhich phosphorylate proteinsare encoded byof the human genome and are critically involved in diverse conditions such as cancermetabolic disorders and neurodegenerationCurrent scientific tools for detecting cellular phosphorylation are limitedbecause most tools examine this proc ...

SummaryThird generationlong read sequencing technologies are increasingly sought after for the analysis of difficult genomic regionssuch as the major histocompatibility complexMHCthe human leukocyte antigenHLAloci and genomes of cancerspathogens and viral insertionsas well as plant and animal genomesSuch methods provide researchers with more contextual informationenabling analysis of highly comple ...

ABSTRACT Asthma is prevalent in overof the pediatric populationwith most pediatric patients uncontrolled or poorly controlled in their diseaseExtensive inflammation of the airways in asthma is treated using inhaled corticosteroidsICSas a maintenance therapyHoweverthese drugs can suppress growth in childrenand fear of this outcome can lead to non adherence in pediatric patientsThis results in sever ...

Project Summary Laparoscopic surgeryreferred to as minimally invasive surgeryis a surgical technique in which operations in the abdominal or pelvic cavities are performed through smallmmincisionsIt is now considered the standard of care for many procedures on female pelvic floor which account for approximatelymillion cases per year in the U SThe laparoscopic technique includes traditional minimall ...

The goal of this SBIR Phase I is to prevent risky sexual behaviors among young female adolescents in order to reduce negative outcomes such as early pregnancy and sexually transmitted infectionsTo accomplish this goalwe propose using state of the art technology to develop a scalable and multicultural version of the efficacious Mighty Girls program and evaluate its usability and feasibilityEarly se ...

ABSTRACTPerinatal hypoxic ischemic encephalopathyHIEaffectstoinfants per everybornMortality from HIE can be up toand approximatelyof survivors suffer significant longterm disability including cerebral palsyepilepsyand developmental disordersDamage during the acute phase of HIE is caused by a deficit in oxygen and glucose in the brainHoweverincreasing evidence indicates that secondary and tertiary ...

ABSTRACTNonsteroidal anti inflammatory drugsNSAIDsare the most commonly prescribed drugs to treat posttraumatic inflammation and painalthough they carry significant risk of seriousdose dependent adverse eventsCorticosteroidswhich are an alternative class of anti inflammatory drugsare rarely prescribed for post traumatic inflammationdue to adverse effects on wound healing and their lack of specific ...